True or False and why? If a drug was developed that can act specifically as an antagonist at presynaptic D2 receptors, this would result in decreased dopamine release.
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Answer and do explain plz.
True or False and why?
If a drug was developed that can act specifically as an antagonist at presynaptic D2 receptors, this would result in decreased dopamine release.
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- Shown are different derivatives of acetylcholine. A H2N H2N D 1. Which one is expected to lose its ability to bind to the receptor but could elicit CNS side effects? Explain. 2. Which is/are expected to resist metabolism by choline esterase? 3. Which one is not expected to bind and yet prone to metabolism? Explain ZIa. Why is there an adverse interaction between monoamine oxidase inhibitors (MAOIs) often given for psychological disorders and an epi pen? b. Epi pens deliver a fast, large dose of epinephrine and are used by people suffering severe allergic reactions. As an AR agonist, epinephrine plays no role in allergic reactions, so why is it used?What is a side effect of long-term blocking of dopamine receptors? increasing hypofrontality decreased brain matter neuronal death in the basal ganglia overproduction of D2 receptors Explain your answer
- 1a.Arrange these ligands in their order of potencies(high to low) 1b. Choose an appropriate concentration of Propranolol needed to block 50% of epinephrine or isoproterenol induced cAMP production via adrenergic receptors expressed in a cell culture model system. 1c. Which of the following has more affinity to bind to adrenergic receptors? And why?I. EpinephrineII. IsoproterenolIII. PropranololPls explain in detail how the drug affected brain cells at the cellular or molecular level (do not just copy and paste on internet) Please write the details of each one Meth Opiate Receptor GABA Receptors Dopamine ReceptorTrue or false. After dopamine is repressed into the synaptic cleft it can be broken down by two enzymes one of which is acetylcholinesterase ?
- Answer True or False for each of the following: A. a neuronal synapse, facilitation of a post -synaptic response results because of an accumulation of calcium ions from previous pre-synaptic cell action potentials. B. In general, chemical synapses are limited because the signal they produce is “all-or-none” and cannot be significantly modified to reflect a difference in sensory. C. Temporal summation describes the cumulative EPSPs/ IPSPs generated in a post-synaptic cell through more than one synapse.Multipie Choice Question: Which of the following is NOT involved in signal transduction by the B-adrenergic receptor pathway (adrenalin-sensing pathway)? OA Activation of the receptor tyrosine kinase O B. Hydrolysis of GTP OC Activation of protein kinase A Oo. Synthesis of cyclic AMP OE Activation of glycogen phosphorylase OF. Activation of GTP-binding proteinQuestion:- Provide 5 different ways that signal transduction by epinephrine through the β2-adrenergic receptor pathway could be repressed.
- Select All statements that are TRUE regarding the effects of administering a molecule that is a precursor for the synthesis of a neurotransmitter A. Temporarily compensate for neuron cell death by increased release of the neurotransmitter (ex. L-dopa used as treatment for Parkinson’s disease) B. Increase the rate of synthesis of that neurotransmitter C. Block the reuptake of the neurotransmitter back into the axon terminal D. Immediately alter then number of postsynaptic receptors E. Act as an indirect antagonist by activating autoreceptorsFentanyl is an opioid similar to morphine, except, according to the CDC, it is up to 50 times stronger than heroin and 100 times stronger than morphine. Discuss the effects of fentanyl on specific receptors and how the transmission of action potentials is altered. Be sure to focus only on how the action potential transmission is impacted by the drug. Be sure to provide an APA citation.Identify the structure highlighted in green: Epinephrine receptor ACh receptor Norepinephrine receptor