The STR DNA marker DS11 is located on the p arm of the chromosome #8 in humans. Molecular analysis has shown that Charlie Chaplin is a heterozygote for the STR marker (genotype DS11A and DS11B) Using this knowledge, provide a diagram of meiosis showing only the movements of chromosome 8 (assume no nondisjunction). Throughout, indicate where the marker may be found (in other words, label the chromosome to show where the STR markers can be found. (Show ONLY the chromosomes at interphase, metaphase 1, end of meiosis 1, metaphase 2, and end of meiosis 2).
Genetic Variation
Genetic variation refers to the variation in the genome sequences between individual organisms of a species. Individual differences or population differences can both be referred to as genetic variations. It is primarily caused by mutation, but other factors such as genetic drift and sexual reproduction also play a major role.
Quantitative Genetics
Quantitative genetics is the part of genetics that deals with the continuous trait, where the expression of various genes influences the phenotypes. Thus genes are expressed together to produce a trait with continuous variability. This is unlike the classical traits or qualitative traits, where each trait is controlled by the expression of a single or very few genes to produce a discontinuous variation.
The STR DNA marker DS11 is located on the p arm of the chromosome #8 in humans. Molecular analysis has shown that Charlie Chaplin is a heterozygote for the STR marker (genotype DS11A and DS11B)
Using this knowledge, provide a diagram of meiosis showing only the movements of chromosome 8 (assume no nondisjunction). Throughout, indicate where the marker may be found (in other words, label the chromosome to show where the STR markers can be found. (Show ONLY the chromosomes at interphase, metaphase 1, end of meiosis 1, metaphase 2, and end of meiosis 2).
Suppose Charlie conceived a son with a chromosome 8 trisomy. Molecular analysis of the STR DS11 marker revealed that his son carried two copies of the DS11A marker and a DS11C marker. Based on the data, determine if the nondisjunction occurred in Charlie or in the mother? Provide your reasoning.
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