The following figure shows how the activities (y-axis) of Cdk-Cyclin B complex and the APC complex change through the cell cycle. Active Cdk1-Cyclin Inactive Cdk1-Cyclin Active APC A B A B time A. When would mitosis and interphase occur on the x-axis? A or B, which is A & which is B B. Does the concentration of cdk1 change during the cell cycle? Explain briefly the increase in activity observed C. Provide one feedback that would a change in Cdk-Cyclin B complex activity. Explain briefly

The following figure shows how the activities (y-axis) of Cdk-Cyclin B complex and the APC complex change through the cell cycle. Active Cdk1-Cyclin Inactive Cdk1-Cyclin Active APC A B A B time A. When would mitosis and interphase occur on the x-axis? A or B, which is A & which is B B. Does the concentration of cdk1 change during the cell cycle? Explain briefly the increase in activity observed C. Provide one feedback that would a change in Cdk-Cyclin B complex activity. Explain briefly

Biology: The Dynamic Science (MindTap Course List)

4th Edition

ISBN:9781305389892

Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Chapter10: Cell Division And Mitosis

Section: Chapter Questions

Problem 8TYK: Which of the following statements about cell cycle regulators is incorrect? a. The concentrations of...

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You are studying three proteins that you think are important Yor progression through the cell cycle. You know that one of them is a phosphatase (P1) and the other two are kinases ( K1 and K2). You add these enzymes in different combinations as shown below, and find that they have different effects on the activity of a cyclin dependent kinase, cdk2p. cdk2p Inactive Active cdk2p + K1 cdk2p + K2 Inactive cdk2p + K1 + K2 Inactive cdk2p + P1 cdk2p + P1 + K2 cdk2p + P1 + K1 Inactive Inactive Active cdk2p + P1 + K1 + K2 Active
Which of the following would result in cell cycle arrest? O phosphorylation of Rb by G1-Cdk phosphorylation of p53 O phosphorylation of helicase by S-Cdk phosphorylation of M-Cdk by CAK phosphorylation of APC by M-Cdk
In mammalian cells, different cyclin-CDK complexes regulate progression of cells through the cell cycle. Which of the following would be true during the cell cycle? Select all that apply Cyclin D phosphorylates and activates MCM protein, a helicase Cyclin B phosphorylates and breaks down the nuclear lamina OThe anaphase promoting complex, or APC/C is phosphorylated and activated by cyclin B Cyclin D helps promotes passage through the restriction point
The following figure shows how the activities (y-axis) of Cdk-Cyclin B complex and the APC complex change through the cell cycle. Active Cdk1-Cyclin Inactive Cdk1-Cyclin Active APC A B A B time
Explain the role of CDK inhibitors. If cyclin-CDK complexes are necessary to allow regulated progression through the eukaryotic cell cycle, what would be the physiological rationale for CDK inhibitors?
This phosphatase removes an inhibitory phosphotyrosine phosphate from serine protein kinase, mentioned in question 6, which activates kinase. What phosphatase is it? This is what question 6 says....This is the serine protein kinase that when activated in a complex cyclin, controls onset of mitosis and M-phase of the cell cycle. 1. Cyclin A/B 2. Wee 1 3. TOR (Target of Rapmycin) 4. Cdk1 5. none of the these ***I believe the answer is Cdk1 for number 6, but I could be wrong
The destruction of the various cyclins is commonly used to inactivate the Cdk/cyclin complexes. Why is it advantageous to inactivate these complexes via protein destruction instead of some other method that does not require the re-synthesis of a cyclin protein the next time the cell divides?
During M phase of the cell cycle, how M-Cdk can trigger cohesin dissociation?
Which subunits activate CDKs at different cellcycle stages. Cyclins are present only in the cell cycle stagesthat they promote.
(Q) During M-phase of cell cycle, active M-Cdk phosphorylates several target proteins in order to regulate their activities. Identify TWO specific examples of such target proteins that are phosphorylated by active M-Cdk, and explain how each of them affects the cell (i.e. their respective biological significance). i) target protein phosphorylated: _______________________________ Biological Significance: ii) target protein phosphorylated: _______________________________ Biological Significance:
(46) A mutated form of protein p5x is found in patients with squamous cell carcinoma. In vitro studies show that the normal p5x molecule binds to DNA, and neoplastic cells accumulate in the G0 phase of the cell cycle. In contrast, the mutated form of p5x does not bin d to DNA. These finding are most characteristics of which of the following? (A) Growht factor receptors (B) GTP-binding protein (C) Nonreceptor tyrosine kinases (D) Oncogene proteins (E) Tumor suppressor gene proteins
13) A phosphotase removes an inhibitory phosphotyrosine phosphate from the serine protein kinase, in MPF whcih activates the kinase and triggers the initiation of mitosis. true or false