StompOnStep1.com a. Assume this pedigree represents inheritance of a human disease. What is the most likely mode of inheritance for this disease? b. What is the most likely genotype person III-IV if we use A and a as the alleles for this disease? a. Autosomal dominant, b. Aa a. Y linked, b. Aa a. Autosomal dominant, b. AA a. Autosomal recessive, b. aa
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- Generation a. What is the genotype of the mother? b. What is the genotype of the father? c. What are the genotypes of the five children" 41. What is/are the possible inheritance pattern(s) for the characteristic in the following pedigree? 11 a. Autosomal recessive only i b. Autosomal dominant only) c. X-linked recessive only d. X-linked dominant only e. All of the above are possible. 42. What is/are the possible inheritance pattern(s) for the characteristic in the following pedigree? 11 a Autosomal recessive only b. Autosomal dominant only c. X-linked recessive only d X-linked dominant only e. All of them are possible. 43. If the phenotype followed in the pedigree below is X-linked recessive, then the genotype of 11-2 is HI a homozygous dominant b heterozygous chomozygous recessive d hemuzygous dominant e bemizygous recessive. Assuming no involvement of the Bombay phenotype(in case you’ve already read ahead to Section 3.2):a. If a girl has blood type O, what could be the genotypes and corresponding phenotypes of her parents?b. If a girl has blood type B and her mother has bloodtype A, what genotype(s) and correspondingphenotype(s) could the other parent have?c. If a girl has blood type AB and her mother is alsoAB, what are the genotype(s) and correspondingphenotype(s) of any male who could not be thegirl’s father?Retinitis pigmentosa, a form of blindness in man, maybe caused either by a dominant autosomal gene R, or a recessive autosomal gene a. An afflicted man whose parents are both normal marries a woman with genotype AaRr. a. What proportion of the children are expected to suffer from this affliction if R and A are inherited independently? b. If this couple want to have normal children only, what isthe probability of having normal children?
- Complete the following queatione BEFORE ATTEMPTING THE HW 1 BLACKBOARD ASSIGNMENT, In the following human pedigrees, the filled symbols represnent the affected individuals who suffer from the disease. Use A/a to represent alleles for autosomal traits and XIX/Ytorepresent alleles for X-linked traits. Use the uppercase letter to represent the dominant allele and the lowercase letterto represent the receasive allele. afected fomale Unafected female affected male Unaffected male Pedigree 1: A. What is the most likely mode of inheritance of this disease? Choose from: autosomal dominant, autosomal recessive, X-linked dominant, X-linked recessive. B. State the genotypes of individuals #1-#3. C. What is the probability that individual #4 is a carrier of this disease if his mother is homozygous dominant and his father is heterozygous? Pedigree 2: What is the most likely mode of inhentance of this disease? Choose from: autosomal dominant, autosomal recessive X-linked dominant X-linked recessive.…Could the characteristic followed in the pedigree be caused by an autosomal dominant disease? Why or why not? 3 4. O No, the offspring of 1-3 and I-4 contradict an autosomal dominant inheritance O No. the offspring of 1-1 and I-2 contradict an autosomal dominant inheritance O Yes, all individuals fit the autosomal dominant inheritance pattern ONo, the offspring of II-3 and -4 contradict an autosomal dominant inheritanceShaded in black-white trait (Glucose-6-phosphate dehydrogenase deficiency) 1. What type of x-linked inheritance is shown in the chart above? a. X-linked Dominant b. X-linked Recessive c. Autosomal Dominance d. Autosomal Recessive 2. What is the genotype of individual 1 at generation I? a. XGXG b. XGXg c. XX d. XO
- re ||| E 6. Label the genotypes for this pedigree of an X-linked recessive disorder (red- green colorblindness). (a) 2 2 3 1 3 a. How do you know? b. Label the genotypes. 4 O To 2 4 5 5 6 6 7. Is the following pedigree autosomal recessive, autosomal dominant or X-linked recessive? 2 8 O T 58.Certain forms of human color blindness are inherited as X-linkedrecessive traits. Hemizygous males are color-blind, but heterozygous females are not. However, heterozygous females sometimeshave partial color blindness.A. Discuss why heterozygous females may have partial color blindness.B. Doctors identified an unusual case in which a heterozygousfemale was color-blind in her right eye but had normal colorvision in her left eye. Explain how this might have occurred.III. For each of these three pedigrees, determine the likely mode of inheritance and the probability that individual will express the trait. A. B. I C. III || IV Mode of inheritance I || IV Mode of inheritance I || O III 04-0 오ㅜㅁ 오ㅜㅁㅇㅁ IV O Mode of inheritance = O P() expresses trait = P() expresses trait = OD P() expresses trait =
- . Males have hemophilia when they are hemizygous fora nonfunctional recessive mutant allele of the X-linkedgene for clotting factor VIII. Factor VIII is normallysecreted into the blood serum by cells in the bonemarrow (and other specialized cells) that produce it.a. Do you think that females heterozygous for thehemophilia disease allele could have hemophiliain some parts of their bodies and not others?b. If such a female carrier of hemophilia suffered acut, would her blood coagulate (form clots) faster,slower, or in about the same time as that of an individual homozygous for a normal allele of the factorVIII gene? Would the rate of clotting vary significantly among heterozygous females?While studying of the family tree with history of hypertrichosis (hyper hirsutism of the ear) this sign was founded only in the men and it was inherited from father to the son. Define the type of hypertrichosis inheritance? Select one: a. Y-linked b. Autosomal-recessive O c. Autosomal-dominant d. Recessive, X-linked e. Dominant, X-linkedFigure 16.4 Two common patterns of autosomal inheritance in humans. & Both parents are heterozygous. b. One parent is heterozygous, and the other is homozygous recessive. The alleles stands for any trait that is dominant, and the letter a stands for any trait that is recessive Substitute the correct alleles for the problems you are working on. For example, C normal, c- cystic fibrosis Parents d 9 A A An X eggs Offspring m Key Dominant allele Recessive allele Dominant phenotype Recessive phenotype Phenotypic Ratio words A a Parents AT X Ag 40 eggs Offspring an A An an Key A Dominant allele Recessive allele Dominant phenotype Recessive phenotype Phenotypic Ratio Autosomal Disorders 1. Neurofibromatosis (NF), sometimes called von Recklinghausen disease, is one of the most common genetic disorders. It affects roughly 1 in 3,000 people. At birth or later, the affected individual may have six or more large, tan spots on the skin. Such spots may increase in size and number and become darker.…