Sickle cell anemia is a genetic disease that causes red blood cells to form incorrectly, slowing the movement of blood and causing tissue damage. A person can be homozvgous dominant for normal blood cell shape, heterozygous or homozygous for sickle cells. Using this information and the figure below, determine the type of inheritance pattern that the sickle cell disorder follows.

Sickle cell anemia is a genetic disease that causes red blood cells to form incorrectly, slowing the movement of blood and causing tissue damage. A person can be homozvgous dominant for normal blood cell shape, heterozygous or homozygous for sickle cells. Using this information and the figure below, determine the type of inheritance pattern that the sickle cell disorder follows.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter10: From Proteins To Phenotypes

Section10.7: Defects In Transport Proteins: Hemoglobin

Problem 2EG

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Sickle cell anemia is an inheritable red blood cell disorder that results in sickle-shaped red blood cells. The sickle-shaped red blood cells can stick to blood vessel walls and cause a blockage or slow the movement of blood throughout the body. Individuals who are heterozygous produce both normal and sickle-shaped red blood cells which gives them resistance to malaria but they do not develop sickle cell anemia (so heterozygotes are unaffected on the pedigree).Let HbS be the allele for sickle cell anemia and let HbA be the allele for normal red blood cells. Which of the following rows provides the correct genotypes for individuals I-2, I-4, II-1, and III-1? Select one: a. I-2 I-4 II-1 III-1 HbA_ HbAHbS HbAHbS HbA_ b. I-2 I-4 II-1 III-1 HbA_ HbAHbS HbAHbS HbAHbS c. I-2 I-4 II-1 III-1 HbAHbS HbAHbS HbAHbS HbAHbS d. I-2 I-4 II-1 III-1 HbAHbA HbAHbA HbAHbA HbAHbA
Astigmatism and polydactyly are dominant over normal vision and finger traits. Sickle-cell anemia onthe other hand, is an overdominant lethal trait due to its recessive genes (ss). Individuals with this traitdie prematurely. Heterozygotes (Ss), however, have some RBCs that sickle while others remainnormal, thus, not lethal. They are referred to as sickle-trait carriers. A polydactylous, normal-visioned, brown-eyed man with wavy hair has a nonpolydactylous, blue-eyed mother. He proposed marriage to a nonpolydactylous, astigmatic, blue-eyed, and curly-hairedlady whose mother has normal vision. However, the lady is worried about the proposal since sickle-cell anemia has been known to run in both their families. a. Is there a genetic basis for her worry? Explain. b. If it turned out that the lady is a carrier and the man has normal RBC, what would be their COMPLETE genotypes? Male genotype:_________________________________Female genotype: ______________________________ c. Based on their…
Astigmatism and polydactyly are dominant over normal vision and finger traits. Sickle-cell anemia onthe other hand, is an overdominant lethal trait due to its recessive genes (ss). Individuals with this traitdie prematurely. Heterozygotes (Ss), however, have some RBCs that sickle while others remainnormal, thus, not lethal. They are referred to as sickle-trait carriers. A polydactylous, normal-visioned, brown-eyed man with wavy hair has a nonpolydactylous, blue-eyed mother. He proposed marriage to a nonpolydactylous, astigmatic, blue-eyed, and curly-hairedlady whose mother has normal vision. However, the lady is worried about the proposal since sickle-cell anemia has been known to run in both their families. a. Is there a genetic basis for her worry? Explain. b. If it turned out that the lady is a carrier and the man has normal RBC, what would be their COMPLETE genotypes? Male genotype:_________________________________Female genotype: ______________________________ c. Based on their…
Complete a new Punnett square below, for a woman who is a carrier for sickle cell, who is married to a man who has sickle cell. What are the possible genotypes that you can identify, what is the ratio of phenotypes that are possible, and what is the chance that any of the offspring are affected by sickle cell anemia?