QUESTION 8The Bohr effect refers tothe decrease in affinity of Hb for 02 when the pH goes up.A.the decrease in affinity of Hb for 02 when the pH goes down.B.the increase in affinity of Hb for O2 when the 02 concentration goes up.C.the decrease in affinity of Hb for O2 when the BPG concentration goes up.OD.the decrease in affinity of Hb for O2 when the BPG concentration goes down.OUESTI ON 9

Bohr effect increases the carbon dioxide levels which lowers the blood pH which results in affecting…

QUESTION 8 The Bohr effect refers to the decrease in affinity of Hb for 02 when the pH goes up. the decrease in affinity of Hb for 02 when the pH goes down. B. the increase in affinity of Hb for 02 when the O2 concentration goes up. C. the decrease in affinity of Hb for O2 when the BPG concentration goes up. D. the decrease in affinity of Hb for 02 when the BPG concentration goes down. OE.

QUESTION 8 The Bohr effect refers to the decrease in affinity of Hb for 02 when the pH goes up. the decrease in affinity of Hb for 02 when the pH goes down. B. the increase in affinity of Hb for 02 when the O2 concentration goes up. C. the decrease in affinity of Hb for O2 when the BPG concentration goes up. D. the decrease in affinity of Hb for 02 when the BPG concentration goes down. OE.

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter1: Introduction To Physiology And Homeostasis

Section: Chapter Questions

Problem 2TAHL

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The Bohr effect refers to: a. the decrease in affinity of Hb for O2 when the pH goes down b. the decrease in affinity of Hb for O2 when the pH goes up c. the increase in the affinity of Hb for O2 when the O2 concentration goes up d. the decrease in affinity of Hb for O2 when the BPG concentration goes up e. the decrease in affinity of Hb for O2 when the BPG concentration goes down
Consider a buffer solution that contains 0.55 M NH2CH2CO2H and 0.35 M NH2CH2CO2Na. pKa(NH2CH2CO2H)=9.88. a. Calculate its pH. b. Calculate the change in pH if 0.155 g of solid NaOH is added to 250 mL of this solution. c. If the acceptable buffer range of the solution is ±0.10 pH units, calculate how many moles of H3O+ can be neutralized by 250 mL of the initial buffer.
Acetazolamide is a drug which inhibits carbonic anhydrase. Carbonic anhydrase participates in regulation of the pH and bicarbonate content of a number of body fluids. Figure 2 shows the experimental curve of initial reaction velocity (as percentage of Vma) versus [S] (concentration) for the carbonic anhydrase reaction. The graph also shows the curve in the presence of acetazolamide. 100 No inhibitor 50 Acetazolamide 0.2 0.4 0.6 0.8 [S] (mM) Figure 2 (i) Compare the maximal velocities and Michaelis Menten constants of the enzyme in the absence and the presence of the inhibitor acetazolamide. Determine the nature of inhibition by acetazolamide. Explain your answer. (ii) Name TWO (2) other types of inhibitions besides the inhibition shown by acetazolamide. Sketch a graph of V versus [S] showing curves in the absence of an inhibitor and in the presence of the types of inhibitors not shown by acetazolamide. ("AJO %) A
Acetazolamide is a drug which inhibits carbonic anhydrase. Carbonic anhydrase participates in regulation of the pH and bicarbonate content of a number of body fluids. Figure 2 shows the experimental curve of initial reaction velocity (as percentage of Vmax) versus [S] (concentration) for the carbonic anhydrase reaction. The graph also shows the curve in the presence of acetazolamide. 100 No inhibitor 50 Acetazolamide 0.2 0.4 0.6 0.8 (S] (mM) Figure 2 (i) Compare the maximal velocities and Michaelis Menten constants of the enzyme in the absence and the presence of the inhibitor acetazolamide. Determine the nature of inhibition by acetazolamide. Explain your answer. (*"A JO %) A
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A doctor wants to prescribe a 70 kg patient a drug to be taken PO. In order to achieve an average steady-state plasma concentration (Css) of this drug in its therapeutic range, the patient needs to have a of Css of 597 μg/L. The VD of this drug is 2.3 L/kg, the F of this drug is 0.70, and the half-life of this drug is 12.9 hours. What is the necessary dosing regimen needed to achieve the desired Css? (units: mg/day, i.e., mg/24 h))