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- Question 1 a. What are the potential roles for calcium sparks in cardiac disease states? b. Describe in detail why if someone who has blood group type A were given a transfusion of blood group type B, they would get an immune reaction?A 100 ml vial of alteplase, a thrombolytic drug, contains 100 mg of drug equivalent to 58,000,000 international units to be administered via intravenous infusion. Determine the units administered to a patient who weighs 172 lb at a dose of 0.9 mg/kg and the volume of injection to use. 43,100,200 units: 78.60 mL 50,810,000 units: 75.50 mL O45,500,700 units: 73.80 mL 40,808,800 units: 70.40 mLA child weighing 22 lbs, has an infection and the doctor orders erythromycin drops 2.0 mLp.o. q6h. The bottle states that the usual dosage is 20.0-40.0 mg/kg/day, and there are35.0 mg per 1.5 mL. Find the min and max dosage per day in mL. Is the order within therecommended dosage?
- The normal induction dosage that my wife gives for the drug Propofol is 1.8 mg/kg How much propofol should she give her 85kg patient to make them go to sleep?A 158lb adult male diagnosed with endocarditis has an order for gentamicin 3mg/kg/day IV in 2 divided doses, in addition to vancomycin. The Gentamicin is available in 2 mL vials containing 40mg/mL. The facility protocol is to round the gentamicin dose to the nearest 10mg, then calculate the volume of solution to the nearest tenth mL. How many mL will administer per dose?A 30-year-old female patient with uncontrolled hypertension is suspected by an investi- gating endocrinologist of having Conn's syndrome. Results of routine biochemistry were (reference ranges are given in brackets): Sodium Potassium Urea Creatinine Alkaline phosphatase Alanine aminotransferase Albumin Bilirubin Calcium 146 mmol/L 2.1 mmol/L 7.2 mmol/L 146 μmol/L 290 IU/L 20 IU/L 49 g/L 8 μmol/L 2.19 mmol/L (135-145) (3.5-5.0) (3.5-6.6) (70-150) (95-320) (5-42) (35-50) (<17) (2.12-2.62) (a) Are any of the electrolyte concentrations abnormal, and if so what condition is suggested? (b) What further biochemistry investigations would you undertake? Explain your reasoning.
- Assume that Ali (same patient in question 1) was prescribed vancomycin 1000 mg every 36 hours. After few days, Steady-state vancomycin concentrations were obtained before and after the fourth dose, and the peak concentration (obtained ½ hour after a 1- hour infusion of vancomycin) was 34 µg/mL while the trough concentration (obtained immediately before dosage administration) was 2.5 pg/mL. Compute a revised vancomycin dose for this patient to provide a steady-state peak concentration of 48 ug/mL and a steady- state trough concentration of 17 pg/mL. a. Estimate new rate constant (Ke) and half-life (t1/2) b. Estimate volume of distribution (Vd) using this equation Cmaxss + Cminss C. Calculate the new dose interval d. Calculate the new doseQuestion: 1. Peripheral arterial disease For this disease pathology, please provide the following information: What causes this disorder (pathology)? Are there any threats to life risks associated with this disease that you should watch out for, and why? (Not all terms will have life-threatening conditions associated with them) What types of lab work or diagnostic testing (ECG, X-ray, ultrasound, MRI, etc.) would you typically see ordered with this disease? What would you expect to see in the lab or diagnostic results? What are the most common treatments? Which treatments would be the most important or take priority?One general guideline for the maintenance dosing of heparin in pediatric patients is 100 units/kg every4 hours, or 20,000 units/m²/24 hour administered continuously. The a vailable injection for use by intravenous infusion contains 1000 USP Heparin Units/mL For a 44-lb child, measuring 42 inches in height, calculate the difference between the quantities of heparin administered over a 24-hour period in (a) heparin units, (b) in milligrams of heparin (sod ium), and (c) in milliliters of heparin injection.
- Question 14 Which of the following medications do you expect the doctor to prescribe to a client with a history of COPD who presents with acute respiratory distress? Question 14 options: Bronchodilators, corticosteroids, and antihypertensives Bronchodilators, corticosteroids, and psychotropics Bronchodilators, diuretics, and antihypertensives Corticosteroids, oxygen, and dirueticsIn pediatric systolic or pulseless arrest, Epinephrine (1 mg/mL, 1mL amp) is dosed at 0.01mg/kg with a maximum single dose of 1mg every 3-5 minutes until with ROSC. Epinephrine is prepared by mixing 1mg of Epinephrine with 9mL of NSS, and this is the stock solution in which the doses to be administered are aspirated.Patient YH, weighing 26kg, was found unresponsive and pulseless. ACLS was started. What is the appropriate volume (in 2 decimal places) to be aspirated from the Epinephrine admixed solution per dose?The instructions for the azithromycin state to reconstitute the 600 mg vial with 3.6 mL until dissolved, to yield a strength of 150 mg/mL, and then to add it to 270 mL of D5W and administer over at least 60 minutes. At what rate will you set the infusion pump if you choose to administer the medication over 90 minutes? order: