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- Pyruvate dehydrogenase can be activated byPyruvate Dehydrogenase Complex:Of the allosteric enzymes listed below, which are suppressed by NADH? Select all that apply. the pyruvate dehydrogenase complex a-ketoglutarate dehydrogenase complex U isocitrate dehydrogenase pyruvate kinase Ophosphofructokinase hexokinase Oglucokinase
- Pyruvate dehydrogenase activity is regulated in part by the concentration of acetyl COA. Name three metabolic pathways that can effect acetyl CoA levels, thus effecting the regulation of the Kreb Cycle.Which citric acid cycle enzyme utilizes a similar reaction mechanism to pyruvate dehydrogenase? O Malate dehydrogenase Isocitrate dehydrogenase O Alpha-ketoglutarate dehydrogenase Succinate dehydrogenaseBriefly describe the role and location of each cofactor/coenzyme involved in the pyruvate dehydrogenase reaction.
- Which precursors accumulate in patients with niacin deficiency. What effect does this deficiency have on the pyruvate dehydrogenase enzyme complexThe co-enzyme that helps in the removal of carbon dioxide from pyruvate during the PDH mechanism is Pyruvate oxidative decarboxylase CoA NAD+ Thiamine PyrophosphatePyruvate can be converted into two different products depending on whether oxygen is readily available or not. Under conditions of strenuous activity (anaerobic) the product is: аcetyl CoA pyruvate lactate CO2
- Pyruvate dehydrogenase catalyzes the conversion of pyruvate to acetyl CoA. In this reaction, one molecule each of the catalytic coenzymes TPP, FAD and lipoamide participate in the reaction but are not consumed. OTrue O FalseMost defects in pyruvate dehydrogenase complex are due to mutations in ______, so supplements with ______ are given. E2 and TPP E1 and lipoamide E3 and NAD+ E2 and lipoamide E1 and TPPElevated levels of acetyl-CoA will act as an effector for which of the following enzymes? Pyruvate carboxylase. Pyruvate kinase Pyruvate dehydrogenase. Citrate synthase a-Ketoglutarate dehydrogenase.