Photodynamic therapy results in induction of WAF1 or CIP1 or P21 leading to cell cycle arrest and apoptosis. Justify.
Q: Which of the following is incorrect about an enzyme-catalyzed reaction? a. Its progress can be…
A: Enzymes are biocatalysts that catalyze biochemical reactions in the cell. There are various enzymes…
Q: How much index [18] embalming fluid would you need to mix with 15oz of an index [10] embalming fluid…
A: Embalming fluids are a mixture of formaldehyde, glutaraldehyde, methanol and other solvents. It is…
Q: CRISPR/Cas9 can be used in genome editing. Among the following statements, which one is correct?…
A: Bacteria have evolved various mechanism to resist against the viruses like bacteriophage some of…
Q: 17 What locks all transmembrane proteins in the bilayer? a) Chemical bonds that form between the…
A: Introduction: Membrane proteins are protein molecules that are attached to or linked with the…
Q: Riboflavin gives rise to cofactors: Select one: O a. All of them O b. FAD; FADH2 O c. NAD+; NADH d.…
A: Introduction: Riboflavin is likewise known as Vitamin B2. It is an important food supplement.…
Q: A biochemst wants to dtermine the effect of inhibitor on a certain enzyme. See attached data. Using…
A: Parameters such as Km and Vmax are used for comparing enzyme activities. If we know the initial rate…
Q: Which of the following is incorrect? O a. Metabolic pathways involve mostly intermediates or…
A: Metabolic pathways are very important for a cell to provide energy.metabolic pathways might be…
Q: What metabolic structure is produced from the carbon atoms of each of the following amino acids?…
A: Metabolism of amino acids results in the removal of amino group and entry of the remaining carbon…
Q: Video resource: Biochemistry of carbohydrates by Armando Hasudungan
A: Carbohydrates are organic molecules arranged in form of aldehyde or ketones with multiple…
Q: Table 1 shows the kinetic data that have been obtained for glucoamylase from Aspergillus niger at…
A: Enzymes catalyse the biochemical reactions by decreasing the activation energy. Enzyme kinetics are…
Q: Is there any other way to do this excersise? Aparently the correct answer is 1.32 x10^-4 s^-1
A: Given Values: Volume = 400 μl = 0.004 Litre Moles of the enzyme = 0.2 moles Vmax = 6.6×10-3 M/s Km =…
Q: Glucose molecules produced during photosynthesis contain higher levels of carbon-12 than carbon -13…
A: In nature, two stable isotopes of carbon exist, carbon 12 and carbon 13. Carbon 13 has one extra…
Q: The activity of an enzyme is studied with and without an inhibitor. Specifically, the initial rates…
A: With the following details provided you are first supposed to plot a graph between substrate…
Q: Delimiate the outcome of of the use of cationic porphyrins as the Choice for the treatment of cancer…
A: Photodynamic therapy (PDT) is a marginally invasive therapeutic procedure that can apply selective…
Q: Oxygen is important for cell function and oxygen exchange is a normal phenomenon for oxidative…
A: Cells obtain most of their energy in the form of ATP from oxidation of Sugars like Glucose. The end…
Q: Define how to Predict the amino acid sequence of a putative polypeptideencoded by a cloned gene…
A: A section of DNA thought to be a gene is known as a putative gene. Although the precise function of…
Q: Which of the following pathways would be considered stage 3 catabolism? (Choose all correct…
A: Hi, thank you for posting the question on Bartleby. As per the guidelines, we can answer only one…
Q: Consider a hypothetical DIPLOID organism with ONE PAIR of homologous chromosomes. How many DNA…
A: Note : Hi ! Thank you for the question. We are authorized to answer one question at a time. Since…
Q: Which of the following is incorrect about protein kinase A (PKA)? It is activated by the 2nd…
A: Protein Kinase A is a type of enzyme that can phosphorylate the serine or threonine residues of…
Q: Discuss some of the strategies which have been developed for using nucleic acids as therapeutic…
A: Elucidation of metabolic pathways that are related to a disease combined with the unravelling of the…
Q: If' a substance temporarily interferes with the function of the structure labelled X, which of the…
A: Biological membranes are made up of a double layer of lipid molecules. The phospholipid bilayer is…
Q: Which of the following is incorrect? a. A heterodimer is composed by two identical polypeptide…
A: a) The heterodimer is composed of two different subunits, they are not made up of two identical…
Q: There is parts A-D for the picture provided. A) A peptide has the sequence,…
A: The pKa is the negative value of the logarithm of Ka. The pKa of the ionizable groups of an amino…
Q: Calculate the energy produced (in ATP molecules) achieved by complete oxidation of the hydrolysis…
A: Glycolysis is an oxidative process that is common in both aerobic and anaerobic cellular…
Q: Which of the following is a property of both D-altro O They are found in sucrose. O They are major…
A: Monosacharides are the monomers of Polysaccharides that are joined by Glycosidic bonds .…
Q: What is the activation energy of a reaction that is three times faster at 40.0 °C than it is at 20.0…
A:
Q: 1. Please fully explain (use illustrate where appropriate) the Modes of Enzyme Catalysis exemplified…
A: The active site of chymotrypsin consist of a combination of 3 specific amino acid residues that work…
Q: The sequences of four DNA molecules are given bel ii. TTTCCCGGGAAA AAAGGGCCCTTT iv. GCCGGATCCGGC…
A: DNA molecules are the nucleic acids that contain sugar, phosphate and nitrogenous base. Sugar is…
Q: 5. What was the optimal temperature for amylase? Explain how your iodine test results support your…
A: Starch is a branched homopolysaccharide consisting of alpha-D-Glucose. It has two glycosidic bonds…
Q: The sugars in RNA and DNA are almost identical. The main difference is the presence or absence of…
A: DNA/RNA are polymers of nucleotides. A nucleotide consists of a nitrogenous base(A, T, G, C)…
Q: You are saying that the inhibitor is competitive inhibitor. But according to data Vmax for reaction…
A: Enzyme kinetics can be calculated more accurate by using lb plot which can be constructed by…
Q: Conversion of Glucose to Glucose-6-phosphate O catalyzed by a dehydrogenase O occurs in the…
A: Ans 1. Option C is correct When the glucose enter in the cell, the hexokinase 1 enzyme convert the…
Q: Question displayed in picture. Choices are : neurons, fat, blood brain barrier, liver, muscle,…
A: According to the graph, blood glucose concentration rises as the rate at which glucose is…
Q: Which serves as storage function in animals? 000000 A 海 B xxoo cocoo pe C D
A: Storage function refers to the reserve food material. The excess food is converted into storage…
Q: Draw the condensed structural formulas for the products of the reaction of which is catalyzed by…
A: Enzymes are the biocatalysts that speed up biochemical reactions. These are generally proteins. AST…
Q: During DNA replication, the template sequence 5' ATAGGCC 3' would produce which one of the following…
A: Replication is a biochemical process by which the DNA is synthesized on itself. It is mode by which…
Q: Which of the following is not a type of lipid? Steroids O Glycerides O Enzymes Unsaturated Fatty…
A: 1. Enzymes are not lipids as they are either proteins or RNA. Almost all the enzymes are protein and…
Q: How does the hormone get from its secretory gland to its target tissue? • Are steroid hormones…
A: Since there are multiple questions in the image, I will explain the entire signaling cascade.…
Q: Ok, thank you so much. In case of Km, we cant get the value? Do we just mention that 2.085 on x-axis…
A: Km is the michaelis menton constant which is nothing but substrate concentration half of maximum…
Q: Explain what biochemical pathway/metabolic processes are affected in insulin resistance? How does…
A: Insulin resistance is a medical condition where the cells fail to respond to the hormone insulin.…
Q: Severe alcohol intoxication can lead to deficiency of vitamin Select one: O a. B1;…
A: Alcohol intoxication is a condition which results from consumption of large amount of alcohols in a…
Q: at is nitrogen fixation
A: Answer for the following question is :
Q: Which of the following molecules has one or more functional groups that can act as hydrogen bond…
A: The formation of hydrogen bond depends on the presence of hydrogen attached to an electronegative…
Q: Which of the following is incorrect about the "initial velocity" assumption? O a. Product is not…
A: Initial velocity is one of the parameters of enzyme that can be determined by using the formula Vo=…
Q: High excretion of sodium through the kidneys can cause? a. Low plasma osmolanity, low urine…
A: There is continuous monitoring of the blood sodium levels and blood volume. When either becomes…
Q: consider 15 NADH and 43 FADH2 molecules funneling electrons into the electron transport chain…
A: In glycolysis, a 6-carbon molecule of glucose-6-phosphate is broken down into 3-carbon pyruvate…
Q: Check the box under each structure in the table that is an enantiomer of the molecule shown below.…
A: Enantiomers are mirror images which can not be superimposed, hence, they are non-superimposable…
Q: Tests Leukocytes Nitrite Urobilinogen Protein pH Blood Specific G. Ketone Bilirubin Glucose Unknown…
A: The urine analysis details of two unknown samples (A and B) are given. The interpretations for…
Q: A glucose 6-phosphate dehydrogenase (G6PD) knockout mouse was created but none of the pups survived.…
A: Glucose-6-phoshate dehydrogenase deficiency is a genetic disorder in which hemolysis of red blood…
Q: Show the order of elution from a cation-exchange resin using a buffer pH of 4.5: aspartic acid,…
A: A cation exchange resin is one that exchanges cations. The resin in this is negatively charged. At a…
Photodynamic therapy results in induction of WAF1 or CIP1 or P21 leading to cell cycle arrest and apoptosis. Justify.
Step by step
Solved in 2 steps with 1 images
- MPF plays an important role during the regulation of the cell cycle. give examples that will support this statement.You are studying a drug that leads to cell cycle arrest during mitosis. You examine levels of cyclin and cdk proteins in the cells treated with the drug, and untreated cells as control. Shown below are the Western blot results of protein expression. Drug No Drug Time (minutes) 15 30 45 60 75 0. 15 30 45 60 75 CDK Cydin Which of the following could be a mechanism by which the drug leads to cell cycle, arrest?could you explain a bit more what this sentences mean: The information displayed demonstrates a significant increase in cell proliferation inside the dentate gyrus of mice that were locked in voluntary exercise compared to the control group. The use of 5-Bromo-2'-deoxyuridine (BrdU), a thymidine analog, permits the following of recently formed cells because it is incorporated into the DNA of dividing cells amid the S stage of the cell cycle. The immunocytochemical examination uncovered a 67% increase in BrdU-labeled cells within the running group, meaning upgraded neurogenesis, which is factually noteworthy as shown by the p-value of 0.0001. The observation that the runner group effectively utilized the running wheels given in their cages relates to the increment in BrdU-labeled cells.
- Discuss/explain, in details, the relationship between cell viability and cell vitality and cell apoptosis as suggested by neutral red uptake,TNF-alpha treatment of prostate carcinoma, LNCAP cells decreases cell survival as shown in the graph below. Which of the following would you observe in these cells treated with TNF- alpha? Select all that apply TNF-a 120 100 80 - 60 40 20 0. 24 72 (hrs) Control + TNF-a 100 ng TNFA 10 ng O Activation of extrinsic pathway of apoptosis O Activation of intrinsic pathway of apoptosis Activation of executioner caspases Recruitment of adapter protein FADD to the TNF-alpha receptor LNCAP cell viability (% of control)“Disruption in the pathway of apoptosis & autophagy can lead to different diseases”- explain briefly
- Describe the effects of the mutation causing the p21 promoter to no longer bind p53 on cell signaling pathways and metabolism or cell cycle control.The output of RTK pathways is often the activation of MAP Kinase. Explain how MAPK can lead to activation of a specific subset of proteins, leading to distinct effects in different cell types in response to the same growth signal.After a cell "clears" the G₁ restriction checkpoint, it can proceed into S phase. This S phase entry is achieved by a cyclin dependent kinase (Cdk2) and its cyclin (Cyclin E), but additionally requires the action of a protein kinase (CDC2) as well as a phosphatase (CDC25) enzyme. Explain how these 4 proteins work together to orchestrate S phase entry.
- Dr. Jace is a research officer in a laboratory that studies anticancer treatment. She is interested to test a plant extract for its apoptosis-inducing effect on colon cancer cells. After incubating the cells with the extracts, she is using the FITC Annexin V Apoptosis Detection Kit I by BD Biosciences for her apoptotic assay. Discuss the detection of apoptosis using this kit and include the utilization of flow cytometry in her experiment.cells undergo programmed cell death. Write out the pathway(s), noting the changes (e.g., localization, phosphorylation, activation) When mammalian cells are irradiated, they stop dividing by arresting at cell cycle checkpoint. If the damage persists, the kinase (CdK), Cdk inhibitor, cytochrome c, DNA damage, mitochondria, p53, phosphorylation, transcription. each step. Include: apoptosis, apoptosome, ATM, pro-apoptotic proteins, caspase, Checkpoint Kinase (Chk), cyclin, cyclin-dependeExplain the concept of loss of heterozygosity (LOH). Why do most cancer cells exhibit LOH of one or more genes? How does failure of the spindle assembly checkpoint lead to loss of heterozygosity?
