Part 1 What is the probability that each indicated individual is a carrier of the disease allele? For people with no family history, assume that the probability of carrier status is f(Aa) I. 11. III. IV. Incorrect 1 1 O 0.0096 O 0.0192 Oo Ⓒ 0.25 O 0.125 2 2 A1 1 2 1/2 x 2/3 0.016 0.0768 0 1 (100%) 1/4 1/2 9... Part 2 What is the chance that Individual IV-I will get the disease? Incorrect Individual III-3 has a 100% chance of being a carrier. Individual III-4 has a chance of 0.0768, as calculated from the frequency in the population. Use this information to calculate the chance that the two carriers could have an affected offspring.

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter18: Genetics Of Behavior
Section: Chapter Questions
Problem 14QP: A pedigree analysis was performed on the family of a man with schizophrenia. Based on the known...
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Below is a pedigree for a family into which Individual III-4 has married. He and his spouse, Individual III-3, are visiting a genetic counselor because they are expecting a baby (Individual IV-1). They want to know the chance that the baby will get the autosomal recessive genetic
disease seen in Individual II-2. Overall, in the population, the disease is known to affect 1 in 625 individuals in the population to which this family belongs [assume this frequency is the result of random mating so represents f(aa)]
I.
II.
E
III.
IV.
1
1
2
2 3
1
3
1
4
2
4
5
Transcribed Image Text:Below is a pedigree for a family into which Individual III-4 has married. He and his spouse, Individual III-3, are visiting a genetic counselor because they are expecting a baby (Individual IV-1). They want to know the chance that the baby will get the autosomal recessive genetic disease seen in Individual II-2. Overall, in the population, the disease is known to affect 1 in 625 individuals in the population to which this family belongs [assume this frequency is the result of random mating so represents f(aa)] I. II. E III. IV. 1 1 2 2 3 1 3 1 4 2 4 5
Part 1
What is the probability that each indicated individual is a carrier of the disease allele? For people with no family history, assume that the probability of carrier status is f(Aa)
I.
II.
III.
IV.
2/3
Incorrect
O 0.0096
O 0.0192
O 0
O 0.25
1
O 0.125
1
2
2
3
1
Part 2
What is the chance that Individual IV-I will get the disease?
2
5
1/2 x
0.016 0.0768 0 1 (100%) 1/4 1/2
Incorrect
Individual III-3 has a 100% chance of being a carrier. Individual III-4 has a chance of 0.0768, as calculated from the frequency in the population. Use this information to calculate the chance that the two carriers could have an affected offspring.
X
X
X
Transcribed Image Text:Part 1 What is the probability that each indicated individual is a carrier of the disease allele? For people with no family history, assume that the probability of carrier status is f(Aa) I. II. III. IV. 2/3 Incorrect O 0.0096 O 0.0192 O 0 O 0.25 1 O 0.125 1 2 2 3 1 Part 2 What is the chance that Individual IV-I will get the disease? 2 5 1/2 x 0.016 0.0768 0 1 (100%) 1/4 1/2 Incorrect Individual III-3 has a 100% chance of being a carrier. Individual III-4 has a chance of 0.0768, as calculated from the frequency in the population. Use this information to calculate the chance that the two carriers could have an affected offspring. X X X
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