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out 1 in 1 d as an pused club ation, but person wh probabilit

out 1 in 1 d as an pused club ation, but person wh probabilit

Human Heredity: Principles and Issues (MindTap Course List)
Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter11: Genome Alterations: Mutation And Epigenetics
Section: Chapter Questions
Problem 16QP: Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior...
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Please answer questions 2-4 thank you!
Page < 2. Club foot is one of the most common congenital skeletal abnormalities, with a worldwide incidence of about 1 in 1000 births. Both genetic and nongenetic factors are thought to be responsible for club foot. C.A. Gurnett et al. (2008. American Journal of Human Genetics 83:616-622) identified a family in which club foot was inherited as an autosomal dominant trait with incomplete penetrance. They discovered a mutation in the PITXI gene that coused club foot in this family. Through DNA testing, they determined that 11 people in the family carried the PITXI mutation, but only 8 of these people had club foot. What is the penetrance of the PITXI mutation in this family? is 3. Assume that long ear lobes in humans are an autosomal dominant trait that exhibits 30% penetrance. A person who heterozygous for long ear lobes mates with a person who is homozygous for normal ear lobes. What is the probability that their first child will have long ear lobes? 4. In chickens, comb shepe is determined by alleles at two loci (R, rand P. p. A wainut comb is produced when at least one dominant llele Ris present at one locus and at least one dominant aliele Pis present st a second locus genotype RP). A rose comb is produced when at least one dominant allele is present et the first locus and two recessive alleies are present at the second locus (genotype R op). A pes comb is produced when two recessive alleles are present at the first locus and at lest one dominant allele is present at the second (genotype rr P). If two recessive Bleles ere present at the first and at the second locus (rr pp), singie combis produced. Progeny with what types of combs and in whnat proportions will resuit from the tolowing crosses? What genetic principie is this an exemple of plus (o) sad (5) aso. (a) anuem(e adeus owes RRPP ee d Rrpe Rr D
Transcribed Image Text:Page < 2. Club foot is one of the most common congenital skeletal abnormalities, with a worldwide incidence of about 1 in 1000 births. Both genetic and nongenetic factors are thought to be responsible for club foot. C.A. Gurnett et al. (2008. American Journal of Human Genetics 83:616-622) identified a family in which club foot was inherited as an autosomal dominant trait with incomplete penetrance. They discovered a mutation in the PITXI gene that coused club foot in this family. Through DNA testing, they determined that 11 people in the family carried the PITXI mutation, but only 8 of these people had club foot. What is the penetrance of the PITXI mutation in this family? is 3. Assume that long ear lobes in humans are an autosomal dominant trait that exhibits 30% penetrance. A person who heterozygous for long ear lobes mates with a person who is homozygous for normal ear lobes. What is the probability that their first child will have long ear lobes? 4. In chickens, comb shepe is determined by alleles at two loci (R, rand P. p. A wainut comb is produced when at least one dominant llele Ris present at one locus and at least one dominant aliele Pis present st a second locus genotype RP). A rose comb is produced when at least one dominant allele is present et the first locus and two recessive alleies are present at the second locus (genotype R op). A pes comb is produced when two recessive alleles are present at the first locus and at lest one dominant allele is present at the second (genotype rr P). If two recessive Bleles ere present at the first and at the second locus (rr pp), singie combis produced. Progeny with what types of combs and in whnat proportions will resuit from the tolowing crosses? What genetic principie is this an exemple of plus (o) sad (5) aso. (a) anuem(e adeus owes RRPP ee d Rrpe Rr D
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In some cases, clubfoot can be associated with other abnormalities of the skeleton that are present of birth(congenital), such as spina bifida, a birth defect that occurs when the spine and spinal cord don't develop or close property.In biology, the ear lobes of a human are generally described as a smooth, muscular outermost portion of the ear. It has substantial blood circulation as well as several nervous terminals. In humans, the major purpose of earlobe, is to keep the ears warmer and assist in the maintenence of stability. 

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