Ordinarily, patients with advanced Parkinson’s disease (who have damage to dopamine-releasing axons) move very slowly if at all. However, during an emergency (e.g., a fire in the building), they may move rapidly and vigorously. Suggest a possible explanation.
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Ordinarily, patients with advanced Parkinson’s disease (who have damage to dopamine-releasing axons) move very slowly if at all. However, during an emergency (e.g., a fire in the building), they may move rapidly and vigorously. Suggest a possible explanation.
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- If given the choice of treating Parkinson’s disease pharmacologically with L-Dopa or invasively using deep brain stimulation which option would you pick and why? (L-Dopa One of the first medications developed to treat Parkinson's disease is a substance called L-DOPA (or Levodopa). This medication can be taken to reduce the motor symptoms of Parkinson's. Unfortunately there is no way to reverse or stop the death of the dopamine producing neurons, but L-DOPA is one of a few treatments that can help manage the symptoms. Your task is to investigate what L-DOPA is and explain why taking L-DOPA might reduce the symptoms of the disease. Write at least one paragraph (5 sentences) to explain your findings in the box below. Use the rubric here to make sure you are explaining the situation thoroughly. This should be entirely in your own words. Do not use phrases from the internet if you do not know what they mean. Rubric (use to check your work) Has major the main points misconceptions not understand of this topic Shows a Understands Clearly does complete understanding How do Neurons 100 85 70 50 use neurotransmitters like dopamine? What do neurons do when…In some cases of ADD (attention deficit disorder) the impulsive, erratic behavior can be normalized with drugs that stimulate the central nervous system. Explain this finding in terms of neurotransmitter activity in the brain.
- There are a broad range of anti-epileptic medications currently on the market, with different therapies prescribed for different types and severities of the condition. Given what you have learned about synaptic transmission, which of the following could be a potential therapeutic approach to prevent the spreading of neuronal excitation? (3 correct answers, select all that apply) O A voltage-gated calcium channel blocker/inhibitor selective to glutamate-releasing neurons. O A voltage-gated calcium channel blocker/inhibitor selective to GABA-releasing neurons. O A glutamate receptor blocker (antagonist). O A GABA receptor antagonist. O A glutamate reuptake inhibitor. O A GABA reuptake inhibitor.discuss the excitatory NMDA receptor, the role of the Mg++ ion, and how NMDA activation can produce Long Term Potentiation (which could underlie memory). Finally, what is the seemingly unique involvement of neighboring glia cells in helping to regulate both GABA and Glutamate neurotransmission and why might that glia cell role occurPhenytoin (sodium channel blocker) and ethosuximide (calcium channel blocker) are anti-seizure drugs that stop seizures from happening. These drugs work by inhibiting electrical impulses (action potentials) from occurring. Explain the importance of sodium and calcium channels on a neuron and the reasons why action potentials do not occur when these channels are inhibited. Thank you
- The therapeutic effect of Aricept (generic donepezil) is due toA: binding of the drug to voltage-gated sodium channels.C: the drug producing an IPSP on the postsynaptic membrane.D: the drug causing the reuptake of acetylcholine at the synapse.E: the drug maintaining higher concentrations of acetylcholine at synapseTrue or False: 4) Symptoms of withdrawal are usually the opposite of the effects of the previously used drug. 5) Although their main effects occur in other neurochemical systems, both MDMA (Ecstasy) and cannabis distort the activity of dopamine, suggesting that these drugs have the potential to be addictive. 6) Opioids produce most of their effects by enhancing the release of a variety of neurochemicals from presynaptic axon terminals.If a patient was experiencing difficulty controlling their movement and displaying motor tremors and this problem was seen ONLY in the central nervous system (not PNS), what system in the central nervous system is likely where the dysfunction is located, what neurotransmitter would likely be related to these symptoms, and what would be the effect of blocking reuptake for this neurotransmitter if the patient was given a reuptake inhibitor for this neurotransmitter?
- Fentanyl is an opioid similar to morphine, except, according to the CDC, it is up to 50 times stronger than heroin and 100 times stronger than morphine. Discuss the effects of fentanyl on specific receptors and how the transmission of action potentials is altered. Be sure to focus only on how the action potential transmission is impacted by the drug. Be sure to provide an APA citation.Chlorpromazine and Bromocriptine both have the affinity in the dopamine receptors of the Central Nervous System, Chlorpromazine is use to treat schizophrenia and psychosis whereas Bromocriptine is use to treat parkinson’s disease. Explain the action of these drugs in the dopamine receptor and why they have different effects and clinical use, knowing that they both act on the dopamine receptors.Briefly describe how silent glutamatergic synapses become activated during long term potentiation, describing all of the key neurotransmitters and their post-synaptic receptors and events that give rise to the process.