Nonsteroidal anti-inflammatory drugs, often referred to as NSAIDS, are commonly used to treat minor aches and pains. Four of the most common NSAIDS are: CH

Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
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Chapter10: Alcohols
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Nonsteroidal anti-inflammatory drugs, often referred to as NSAIDS, are
commonly used to treat minor aches and pains. Four of the most common
NSAIDS are:
CH3
H
нн
H
H.
H3C.
OH
CH3
HO.
H
H
CH3
Acetylsalicylic acid
(aspirin)
Ibuprofen
(Advil, Nuprin, Motrin)
H
H.
H
H.
ОН
H3C
Н.
H.
HO.
H.
H
H
CH3
H
H3C
Naproxen
(Naprosyn, Aleve)
Acetaminophen
(Tylenol)
(a) How many sp3-hybridized carbons are present in aspirin?
(b) How many sp2-hybridized carbons are present in naproxen?
(c) What is the molecular formula of acetaminophen?
(d) Aspirin, ibuprofen, and naproxen are all believed to target the
same enzyme, cyclooxygenase, which produces substances called
prostaglandins, that mediate inflammation. Discuss
in the structures of these drugs.
any
similarities
Transcribed Image Text:Nonsteroidal anti-inflammatory drugs, often referred to as NSAIDS, are commonly used to treat minor aches and pains. Four of the most common NSAIDS are: CH3 H нн H H. H3C. OH CH3 HO. H H CH3 Acetylsalicylic acid (aspirin) Ibuprofen (Advil, Nuprin, Motrin) H H. H H. ОН H3C Н. H. HO. H. H H CH3 H H3C Naproxen (Naprosyn, Aleve) Acetaminophen (Tylenol) (a) How many sp3-hybridized carbons are present in aspirin? (b) How many sp2-hybridized carbons are present in naproxen? (c) What is the molecular formula of acetaminophen? (d) Aspirin, ibuprofen, and naproxen are all believed to target the same enzyme, cyclooxygenase, which produces substances called prostaglandins, that mediate inflammation. Discuss in the structures of these drugs. any similarities
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