Munchkin cats have a mutation in the fibroblast growth factor receptor (FGFR3) gene, the same gene mutated in humans suffering from achondroplasia. In cats and humans this causes dwarfism because FGFR3 has a negative effect on bone growth. In achondroplasia, the mutated form of the FGFR3 receptor is constitutively active and this leads to severely shortened bones.A) Draw a simple diagram of the FGFR effect on bone growth in "normal" cats.B) Crossing two munchkin cats always yields 2 munchkin kittens for every 1 normal kitten. True breeding munchkin cats do not exist. Explain this result by showing the genotypes of all parents and offspring. Remember to define your alleles and indicate which is dominant and which is recessive.

When FGF binds to its receptor present on the cell membrane of a skeletal cell it induce the…

Answered: Munchkin cats have a mutation in the…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Munchkin cats have a mutation in the fibroblast growth factor receptor (FGFR3) gene, the same gene mutated in humans suffering from achondroplasia. In cats and humans this causes dwarfism because FGFR3 has a negative effect on bone growth. In achondroplasia, the mutated form of the FGFR3 receptor is constitutively active and this leads to severely shortened bones.

A) Draw a simple diagram of the FGFR effect on bone growth in "normal" cats.

B) Crossing two munchkin cats always yields 2 munchkin kittens for every 1 normal kitten. True breeding munchkin cats do not exist. Explain this result by showing the genotypes of all parents and offspring. Remember to define your alleles and indicate which is dominant and which is recessive.

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