Many common materials that we ingest, though quite safe in reasonable quantities, become toxic when taken in very large doses. A measure of toxicity is the LD 50 value (Lethal Dose, 50%). It is the quantity of material, expressed in mg of material per kg of subject-body-weight that, if administered to a population of subjects, would cause 50% of the population to die. The LD 50 value for FD&C Red Dye No. 40 is >10,000 mg/kg in rats. Assume that the LD 50 value for humans is the same as for rats. Calculate the number of number of glasses of Allura Red sports drink, each containing 9.3 mg of Allura Red, required to reach the LD 50 of 10,000 mg of Allura Red/kg body weight. Assume the person has a body weight of 225 Ibs. 2.205 Ibs = 1 kg %3!

Many common materials that we ingest, though quite safe in reasonable quantities, become toxic when taken in very large doses. A measure of toxicity is the LD 50 value (Lethal Dose, 50%). It is the quantity of material, expressed in mg of material per kg of subject-body-weight that, if administered to a population of subjects, would cause 50% of the population to die. The LD 50 value for FD&C Red Dye No. 40 is >10,000 mg/kg in rats. Assume that the LD 50 value for humans is the same as for rats. Calculate the number of number of glasses of Allura Red sports drink, each containing 9.3 mg of Allura Red, required to reach the LD 50 of 10,000 mg of Allura Red/kg body weight. Assume the person has a body weight of 225 Ibs. 2.205 Ibs = 1 kg %3!

Chemistry: The Molecular Science

5th Edition

ISBN:9781285199047

Author:John W. Moore, Conrad L. Stanitski

Publisher:John W. Moore, Conrad L. Stanitski

Chapter13: The Chemistry Of Solutes And Solutions

Section: Chapter Questions

Problem 57QRT

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