Lucy, a 30 year old opioid addict is taken to hospital and is believed to be suffering from MPTP poisoning. What medication would protect her from MPTP induced parkinsonian syndrome?
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Lucy, a 30 year old opioid addict is taken to hospital and is believed to be suffering from MPTP poisoning. What medication would protect her from MPTP induced parkinsonian syndrome?
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- John Jones, age 33, has been admitted to the hospital for the third time with a diagnosis of paranoid schizophrenia. John had been taking haloperidol (Haldol) but stopped taking it weeks ago, telling his case manager it was “the poison that is making me sick.” Yesterday, John was brought to the hospital after neighbors called the police because he had been up all night yelling loudly in his apartment. Neighbors reported him saying, “I can’t do it! They don’t deserve to die!” and similar statements. John appears guarded and suspicious and has little to say to anyone. His hair is matted, he has a strong body odor, and he is dressed in several layers of heavy clothing even though the weather is warm. So far, John has been refusing any offers of food or fluids. When the nurse approached John with a dose of haloperidol, he said, “Do you want me to die?” What additional assessment data does the nurse need to plan care for John? Identify the three priorities, nursing diagnoses, and expected…John Jones, age 33, has been admitted to the hospital for the third time with a diagnosis of paranoid schizophrenia. John had been taking haloperidol (Haldol) but stopped taking it weeks ago, telling his case manager it was “the poison that is making me sick.” Yesterday, John was brought to the hospital after neighbors called the police because he had been up all night yelling loudly in his apartment. Neighbors reported him saying, “I can’t do it! They don’t deserve to die!” and similar statements. John appears guarded and suspicious and has little to say to anyone. His hair is matted, he has a strong body odor, and he is dressed in several layers of heavy clothing even though the weather is warm. So far, John has been refusing any offers of food or fluids. When the nurse approached John with a dose of haloperidol, he said, “Do you want me to die?” Identify the three priorities, nursing diagnoses, and expected outcomes for John’s care with your rationales for the choices.We talked about drug effects on neurons in sequence. The effect of alcohol is multi-faceted and the following question asks you to apply your knowledge. Imagine two neurons in sequence. The presynaptic neuron is GABAnergic and the postsynaptic neuron is dopaminergic. The effects of alcohol are not fully understood but it does seem to inhibit GABAnergic neurons. How would the release of dopamine from the postsynaptic neuron change in this case? Explain your answer, being sure to make each connection between concepts clear. If alcohol instead inhibited dopaminernergic neurons, in what way might the ion flow change in the dendrites of the postsynaptic neuron of this example?
- Susan Watts, a 30-year-old female client, was diagnosed with schizophrenia and was treated with paliperidone (Invega) 9 mg PO every day and benztropine (Cogentin) 1 mg PO2× a day. The client arrives at the clinic and is exhibiting the following symptoms. She is repeating what is said to her (echolalia) and is telling you that the sirens are loud and the paramedics are working hard to save the man. She yells over at the paramedics, she sees and tells them they are doing a great job. She has a flat affect and is bouncing her knees up and down as she sits staring at the wall where she is seeing and hearing the hallucination. Her husband is with her and stated he is worried about his wife because she has not bathed, washed, or combed her hair for 2 days now. She has not gone to work for the past week. He stated that she keeps failing to take her medications even with reminding. The client’s husband asks the LPN/LVN if there is any way the drug therapy could be managed differently so his…Haloperidol is a drug that interferes with the transmission of dopamine among neurons. What effect would it probably have on someone who is suffering from Parkinson's disease?If given the choice of treating Parkinson’s disease pharmacologically with L-Dopa or invasively using deep brain stimulation which option would you pick and why? (
- L-Dopa One of the first medications developed to treat Parkinson's disease is a substance called L-DOPA (or Levodopa). This medication can be taken to reduce the motor symptoms of Parkinson's. Unfortunately there is no way to reverse or stop the death of the dopamine producing neurons, but L-DOPA is one of a few treatments that can help manage the symptoms. Your task is to investigate what L-DOPA is and explain why taking L-DOPA might reduce the symptoms of the disease. Write at least one paragraph (5 sentences) to explain your findings in the box below. Use the rubric here to make sure you are explaining the situation thoroughly. This should be entirely in your own words. Do not use phrases from the internet if you do not know what they mean. Rubric (use to check your work) Has major the main points misconceptions not understand of this topic Shows a Understands Clearly does complete understanding How do Neurons 100 85 70 50 use neurotransmitters like dopamine? What do neurons do when…Why would a tricyclic antidepressant fit in with the monoamine theory? How does a tricyclic antidepressant work?A benzodiazepine such as Valium inhibits seizures through what action? A) Inhibiting Dopamine Receptors B) Decreasing the amount of Glutamate C) Increasing Norepinephrine Stimulation D) Increasing GABA Action
- Why is it difficult to treat conditions such as Parkinson’s with additional neurotransmitters? What kind of side effects are possible?What does the fact that rotenone appears to increase the susceptibility to Parkinson disease indicate about the etiology of Parkinson disease?Why can’t an individual with Parkinson’s disease be given dopamine to relieve his symptoms?