Ligand binding and response. The following question involves the ligand binding to a receptor and the receptor's response to that ligand. What ligand concentration would be required for a full agonist with a KD of 8 nM to achieve a response of 0.75?
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- Plesae ASAP. thanku Which of the following is not true about the glutamate family of ligand-gated ion channels? a. members are AMPA, kinase, and NMDA channels b. they are cation permable c. channels subunits have 3 full transmembrane doamins d. they require 5 subunits to amke a functional channelFrog poison. Batrachotoxin (BTX) is a steroidal alkaloid from the skin of Phyllobates terribilis, a poisonous Colombian frog (the source of the poison used on blowgun darts). In the presence of BTX, Na+Na* channels in an excised patch stay persistently open when the membrane is depolarized. They close when the membrane is repolarized. Which transition is blocked by BTX?= 20 nM. The rate of receptor-ligand complex formation with an A receptor-ligand complex has a dissociation constant of Ka added ligand concentration of 10 µM is 5 × 10³ s¯¹. What is the value of the reverse rate constant, k_₁ ? k_₁ = 8-1
- SIGNALS AND TARGETS. Listed below are sample polypeptides/proteins with their signal molecule/peptide. Answer the questions that follow. If you are asked to give the amino acid sequence, provide the sequence using the three-letter names of the amino acids (eg. ser-ala-met). Catalase with H2N-...KERINGKERIANGEKSAMSKL-COOH What is the name of the specific receptor of this polypeptide? The receptor may also have what alternative function?Inducers and Inhibitors of AEP. Short peptides such as legumain stabilization and activity modulation (LSAM) domain and αvβ3 integrin could enhance the activity of AEP. LSAM domain known as the prodomain of AEP blocks substrate binding before activation. This prodomain has a helical structure and two independent peptides. One is an activation peptide (AP, K287 to N323), and the other is a LSAM domain. LSAM domain remains even after AP is cleaved and released from protease at neutral pH via electrostatic interaction. AEP without LSAM domain has a lower melting temperature than AEP with LSAM domain [77, 117]. Another short peptide, αvβ3 integrin, can directly interact with AEP, and after forming a complex, the optimal pH for AEP activity is increased from 5.5 to 6.0. It indicates that αvβ3 binding could induce conformational stabilization of AEP accompanied by deprotonated C189. αvβ3 does not directly interact with the AEP active site; however, AEP docks to the αvβ3 RGD-binding site…SIGNALS AND TARGETS. Listed below are sample polypeptides/proteins with their signal molecule/peptide. Answer the questions that follow. If you are asked to give the amino acid sequence, provide the sequence using the three-letter names of the amino acids (eg. ser-ala-met). Protease with mannose-6-phosphate Where is the receptor for this protein located? Where is the final destination of this polypeptide? What happens to the receptor after protein transport?
- 1G. Please help me in detail. For Molecular Mechanism of ATP versus GTP selectivity of adenylate kinase, Write an expression for the reaction velocity.Need help. Plz explain briefly Describe in detail with the aid of diagrams the use of chemical shift perturbation mapping to identify ligand binding sites on a protein.True or False. The binding affinity between a peptide agonist and its specific G protein coupled receptor involves certain types of chemical bonds. Explain your answer in detail.. ( please do not copy off of another source.. e.g chegg)
- True or False. The binding affinity between a peptide agonist and its specific G protein coupled receptor alone determines the sensitivity of a cell to the agonist peptide.Multiple Choice. Imagine a solution containing only water, sodium, and glucose. If a voltage is applied to the solution, glucose would move: (a) There would be no net movement of glucose (b) In the opposite direction of sodium (c) In the same direction and speed as sodium (d) In the same direction as sodium, but slower. (e) In the same direction as sodium, but faster.Only a few. Why do only a small number of sodium ions need to flow through the Na+Na* channel to change the membrane potential significantly?