In the absence of actin, myosin will hydrolyze ATP, but very slowly. Based on the mechanism shown in the figure, what could explain this slow rate? ΟΟ Without actin, the reversible ATP hydrolysis by myosin shifts in favor of ATP synthesis. Without actin, the attacking water molecule cannot easily reach the ATP bound to myosin. Without actin, myosin releases ADP and P; very slowly after hydrolyzing ATP. Without actin, myosin cannot undergo the conformational changes needed to hydrolyze ATP.

Biology 2e
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ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark
Chapter38: The Musculoskeletal System
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In the absence of actin, myosin will hydrolyze ATP, but very slowly. Based on the mechanism shown in the figure, what
could explain this slow rate?
Without actin, the reversible ATP hydrolysis by myosin shifts in favor of ATP synthesis.
Without actin, the attacking water molecule cannot easily reach the ATP bound to myosin.
Without actin, myosin releases ADP and P; very slowly after hydrolyzing ATP.
Without actin, myosin cannot undergo the conformational changes needed to hydrolyze ATP.
Transcribed Image Text:In the absence of actin, myosin will hydrolyze ATP, but very slowly. Based on the mechanism shown in the figure, what could explain this slow rate? Without actin, the reversible ATP hydrolysis by myosin shifts in favor of ATP synthesis. Without actin, the attacking water molecule cannot easily reach the ATP bound to myosin. Without actin, myosin releases ADP and P; very slowly after hydrolyzing ATP. Without actin, myosin cannot undergo the conformational changes needed to hydrolyze ATP.
The figure shows the mechanism by which myosin moves along an actin filament.
Actin
Myosin
ATP
1
ADP
5
ATP
ADP
H₂O
(2)
(ADP.Pi
ⓇL
3
ADP.Pi
Transcribed Image Text:The figure shows the mechanism by which myosin moves along an actin filament. Actin Myosin ATP 1 ADP 5 ATP ADP H₂O (2) (ADP.Pi ⓇL 3 ADP.Pi
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