If polyalanine has a ΔH of -7KJ/mol, ΔS of -0.015KJ/K-mol, and a negative ΔG. If we want to form polyalanine into an alpha helix, how to rationalize the sign for the change in entropy for this formation taking in consideration the peptide and water? Can you please specifically explain the effects of the peptide and water! If polyglutamate spontaneously forms an alpha helix as well, but only when the pH of the solution is below 4.0. Why does it only form at pH lower than 4.0 and how does this relate to the change in enthalpy or entropy that occurs in the random coil —-> helix transition.?
Neutral Amino Acids
Amino acids which do not have any charge on them are neutral amino acids.
Globular Protein
The globular proteins refer to the shape of protein specifically spherical in nature apart from spherical form fibrous, disordered and membrane-bound proteins exist. These globular proteins are miscible in water and form a colloidal solution rather than other types which might not exhibit solubility. Many classes of the fold are found in globular proteins, which render them a sphere shape. Globular fold containing proteins usually are referred to by the term globin.
Dimer
Dimers are basic organic compounds, which are derivates of oligomers. It is formed by the combination of two monomers which could potentially be strong or weak and in most cases covalent or intermolecular in nature. Identical monomers are called homodimer, the non-identical dimers are called heterodimer. The method by which dimers are formed is known as “dimerization”.
Dipeptide
A dipeptide is considered a mixture of two distinct amino acids. Since the amino acids are distinct, based on their composition, two dipeptide's isomers can be produced. Various dipeptides are biologically essential and are therefore crucial to industry.
If polyalanine has a ΔH of -7KJ/mol, ΔS of -0.015KJ/K-mol, and a negative ΔG. If we want to form polyalanine into an alpha helix, how to rationalize the sign for the change in entropy for this formation taking in consideration the peptide and water? Can you please specifically explain the effects of the peptide and water!
If polyglutamate spontaneously forms an alpha helix as well, but only when the pH of the solution is below 4.0. Why does it only form at pH lower than 4.0 and how does this relate to the change in enthalpy or entropy that occurs in the random coil —-> helix transition.?
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