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- Given the Ka values (in parentheses) for the following acids: HSO4– (Ka= 1.2 x 10–2); HNO2 (Ka= 4.0 x 10–4); HC2H3O2 (Ka= 1.8 x 10–5); Calculate Kc values for the following acid-base equilibria: (a) HSO4–(aq) + C2H3O2–(aq) ⇌ HC2H3O2(aq) + SO42–(aq) (b) HC2H3O2(aq) + NO2–(aq) ⇌ HNO2(aq)+ C2H3O2–(aq)Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed antidepressants. SSRIs block the reabsorption of the neurotransmitter serotonin in the brain. Changing the balance of serotonin helps brain cells send and receive chemical messages, which in turn boosts mood. Two SSRI medications are Faverin (fluvoxamine, C15H21F3N2O2 ) and Zoloft (sertraline, C17H17Cl2N ). Determine the molar masses of Faverin and ZoloftI mostly need help setting up how to do the math for these problems. I also need help with knowing how to find which acid is the strongest. Give the Ka or pKa values that should be entered in the blanks below. pKa = -log10ka ; Ka = 10-pKa (a) hydrocyanic acid: Ka = 4.92 x 10-10 ; pKa = (b) acetic acid: Ka = ; pKa = 4.75 (c) lactic acid: Ka = 8.40 x 10-4 ; pKa = (d) formic acid: Ka = ; pKa = 3.75 (e) Which of these acids is the strongest?
- Directions: Identify the type of IMFA for the following substances and answer the questions that follow. You may follow the examples above in answering the questions. Table 1-Substances and IMFA Types 1. CO 2. NH3 3. CCIA Critical Thinking Questions: 1. How do you determine the type of IMFA that in each of the given substances? OCcurs 2. Rank the strength of each compound based on IMFA. (1 = strongest, 2 = in between, 3 = weakest) Explain your answer. 1. %3D %3DHow does the pKe of the conjugate acid of benzylamine (CgH5CH,NH2) compare to the pk,'s of the conjugate acids of cyclohexanamine (10.7) and aniline (4.6)? Explain your choice.The triple amine in an acidic medium does not give a transition n→o * Explain why?
- 4. Which effect does an antagonistic drug have? (a) It inhibits the activity of an enzyme (b) It promotes the activity of an enzyme (c) It inhibits the signalling of a receptor (d) It promotes the signalling of a receptor (e) It promotes nerve signalling 7. Which technique is not used for structural analyses of possible lead compounds? (a) NMR (b) IR (c) X-Ray crystallography (d) MRI (e) MSGive the polarity, melting point, boiling point, solubility, and state at room temperature of the following: PhosphatidyIcholine(28:0) Phosphatidylinositol(34:1) Phosphatidylserine(36:2)3. Which is the stronger acid: (a) Benzoic acid with a Ka of 6.5 x10-5 or hydrocyanic acid with a Ka of 4.9 x 10-10? (b) Boric acid with a pKa of 9.14 or carbonic acid with a pKa of 6.37
- ) The potency of antagonists is frequently defined in terms of either their IC50, ortheir Ki. Explain what these two terms mean.Propranolol binds to beta-adrenergic receptors with a Kj of 8.9 x 10-9M. What concentration of propranolol would be required to achieve a 50% reduction in the binding of the receptor agonist isoproterenol if the agonist concentration is 10ONM and its dissociation constant for the receptor is 4.8 x 10-8 M?You have a solution of NADH (E260 16,900 M1-cm1 and 8340= 6,220 M1-cm), for which the extinction coefficients represent the adenine and reduced nicotinamide groups. If there is a contamination of NAD* of 20% in the sample, what is the A260/A340?