HBV 8 HBV acquires its envelope as it exits from the cell. HBV HBV infects liver cell. 7 Reverse transcriptase uses pgRNA as a template to make DNA but does not Liver cell complete the process, leaving the HBV DNA genome partially single-stranded. After uncoating, the HBV genome is trans- ported to the nucleus. cccDNA Viral particles assemble, and HBV-encoded reverse transcriptase is packaged with the pgRNA. Nucleus pgRNA MRNA The single-stranded gap in the genome is filled in, creating a covalently closed circular DNA molecule (cccDNA). 3 MRNA The mRNA is translated, producing the virally encoded proteins. Viral proteins 4 RNA polymerase transcribes the cccDNA, generating mRNA and pregenomic RNA (pgRNA). FIGURE 24.20 Replication of Hepatitis B Virus

HBV 8 HBV acquires its envelope as it exits from the cell. HBV HBV infects liver cell. 7 Reverse transcriptase uses pgRNA as a template to make DNA but does not Liver cell complete the process, leaving the HBV DNA genome partially single-stranded. After uncoating, the HBV genome is trans- ported to the nucleus. cccDNA Viral particles assemble, and HBV-encoded reverse transcriptase is packaged with the pgRNA. Nucleus pgRNA MRNA The single-stranded gap in the genome is filled in, creating a covalently closed circular DNA molecule (cccDNA). 3 MRNA The mRNA is translated, producing the virally encoded proteins. Viral proteins 4 RNA polymerase transcribes the cccDNA, generating mRNA and pregenomic RNA (pgRNA). FIGURE 24.20 Replication of Hepatitis B Virus

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter5: Structure And Function Of Plasma Membranes

Section: Chapter Questions

Problem 18RQ: Many viruses enter host cells through receptor- mediated endocytosis, What is an advantage of this...

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