Group 3) Replacing an A with a T in a hemoglobin gene is associated with sickle-cell anemia in humans. Normal: 5'- ATGGTGCACCTGACTCCTGAGGAGAAGTCT-3' ATGGTGCACCTGACTCCTGTGGAGAAGTCT-3' Sickle cell: 5'- (a) What is the nucleotide sequence of the normal and sickle-cell hemoglobin mRNA? (b) What is the amino acid sequence in this part of the polypeptide chain, and what is the amino acid replacement that results in sickle-cell hemoglobin? (c) Why might this amino acid substitution make a difference in protein structure?
Group 3) Replacing an A with a T in a hemoglobin gene is associated with sickle-cell anemia in humans. Normal: 5'- ATGGTGCACCTGACTCCTGAGGAGAAGTCT-3' ATGGTGCACCTGACTCCTGTGGAGAAGTCT-3' Sickle cell: 5'- (a) What is the nucleotide sequence of the normal and sickle-cell hemoglobin mRNA? (b) What is the amino acid sequence in this part of the polypeptide chain, and what is the amino acid replacement that results in sickle-cell hemoglobin? (c) Why might this amino acid substitution make a difference in protein structure?
Biology (MindTap Course List)
11th Edition
ISBN:9781337392938
Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Publisher:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Chapter16: Human Genetics And The Human Genome
Section: Chapter Questions
Problem 6TYU
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