Given an = 0.2 Gy-, Bn 0.08 Gy-1 for normal tissue and a,n = 0.5 Gy-1, Bn = 0.05 Gy-1 for tumor, calculate the cell survival fractions for both normal tissue and tumor when 2 Gy of radiation dose is daily delivered during 20 days.
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- Calculate the creatinine clearance for Lola, a 69 year old woman who weighs 66kg and has a serum creatinine of 125micromoles/L. Round your answer to 2 decimal places Cockroft Gault equation: [ X (140-age) x (weight in kg)] / serum creatinine (in micromole/L) Where X = 1.04 for females and X = 1.23 for malesAssume that Ali (same patient in question 1) was prescribed vancomycin 1000 mg every 36 hours. After few days, Steady-state vancomycin concentrations were obtained before and after the fourth dose, and the peak concentration (obtained ½ hour after a 1- hour infusion of vancomycin) was 34 µg/mL while the trough concentration (obtained immediately before dosage administration) was 2.5 pg/mL. Compute a revised vancomycin dose for this patient to provide a steady-state peak concentration of 48 ug/mL and a steady- state trough concentration of 17 pg/mL. a. Estimate new rate constant (Ke) and half-life (t1/2) b. Estimate volume of distribution (Vd) using this equation Cmaxss + Cminss C. Calculate the new dose interval d. Calculate the new doseChoose a range of ODe00 from the data set that can assure a good correlation of viable cell 600 count with optical density. CFU/mL OD. 600 1 X 103 1х 108 0.1 1.75 X 108 0.2 1.9 x 108 0.4 4 x 108 0.7 9 x 108 0.71 Best OD600 range: Correlation coefficient (best fit): Regression equation (best fit):
- Determine the maintenance dose (in mg) of tobramycin for a 65 year old male patient weighing 85 kg and measuring 5 ft 7, in. in height with a serum creatinine of 2.8 mg/dL. The loading dose desired is 1 mg/kg of ideal body weight and 1.8 mg/kg of ideal body weight for the maintenance dose. Report your answer as a whole number.Calculate doses for the drugs indicated below based on the patient's BSA. Calculate the BSA to the nearest hundredth and medication dosages to the nearest tenth. Show complete solutions. 1. An adult who is 68.8 kg and 165 cm needs monthly IV doses of cyclophosphamide for cancer treatment. The recommended monthly dose is 0.5 to 1 g/m2. What is the dose appropriate for this patient? a. If the lowest dose is ordered and cyclophosphamide for IV administration is available as 100 mg/5 mL, how many mL of medication would be added to IV fluid for infusion each month?A cancerous tumour is exposed to an A-emitter with an RBE of 12. What absorbed dose, in Gy, is needed to give the tumour an effective dose of 60 Sv? Report your final answer rounded to two significant digits.
- A cat presents with suspected acute, severe sepsis. The veterinarian asks you to draw up a dose of IV gentamicin. The dosage for a cat with acute sepsis is 2.2 mg/kg. Calculate the dose for an 8-lb cat. The concentration of gentamicin is 50 mg/ml. Show me your calculation Please note that: 1Kg= 2.2 lb22:23 1O 000 · 11:24 A9 OB1 r ll l 52% . +964 782 734 3923 2m541139927815107... Patient Encounter Part 3 The pretreatment workup is summarized below. Pathology: 47-year-old female with new diagnosis of infiltrating intraductal adenocarcinoma involving the left breast and regional node. Further tests on tumor samples indicated ER (8%), PR (negative), HER2 (negative), Ki-67 (72%), and grade (poorly differentiated). Intrinsic subtype (luminal B, HER2-negative). Radiology: FDG-PET/CT indicated a 5.3 x 2.5 cm mass in the left breast which appeared to extend to the epidermis of the skin; one node in the left axilla was also involved with tumor. No other evidence of distant disease was visualized. Laboratory: CBC, liver, and kidney function tests WNL, alkaline phosphatase and calcium are normal also. Stage: IB (T, N, M,) List the most important prognostic factors in this patient with newly diagnosed breast cancer. Assess the patient's level of risk for relapse. 50 SECTION 16 | ONCOLOGIC… Mr. Yeboah, diagnosed with a malignant tumour of the liver had it removed and was given a course of chemotherapy. Initially, tumour marker (AFP) activity activity was 7500KU/L (which is very high) but after treatment, this gradually declined to only 5KU/L. A routine follow up test was perfomedafter 3 months and the results was 15KU/L for AFP. The doctor suspected a relapse of the tumour and so referred Mr. Yeboahto an oncologist at a cancer centre who also did a re-check. AFP was recorded to be 5KU/L. Enquiries revealed that the hospital and the cancer centre use different instruments for the measurement of AFP. Both results are normal even though the values are significantly different because different methods were used.a) How can both labs confirm that the results are not clinically significant? b) How can both labs avoid this happening again?
- One general guideline for the maintenance dosing of heparin in pediatric patients is 100 units/kg every4 hours, or 20,000 units/m²/24 hour administered continuously. The a vailable injection for use by intravenous infusion contains 1000 USP Heparin Units/mL For a 44-lb child, measuring 42 inches in height, calculate the difference between the quantities of heparin administered over a 24-hour period in (a) heparin units, (b) in milligrams of heparin (sod ium), and (c) in milliliters of heparin injection.When can the H-H equation be used clinically/Using two centrifuges (A and B), with maximum speeds of 1500 rpm (r = 8 cm) and 3000 rpm (r = 8 cm), respectively, construct a separation scheme for separating three subcellular structures with the following xg requirements: PAT – 150 xg - SAT – 120,000 xg НАТ - 650 хg