Gain of Function research, defined as: "medical research that genetically alters an organism in a way that may enhance the biological functions of gene products." The worry is that this type of research will lead to the release of dangerous viruses and is unethical; others believe it is necessary to treat future pandemics is Gain of Function research unethical? Why?

Gain of Function research, defined as: "medical research that genetically alters an organism in a way that may enhance the biological functions of gene products." The worry is that this type of research will lead to the release of dangerous viruses and is unethical; others believe it is necessary to treat future pandemics is Gain of Function research unethical? Why?

Biomedical Instrumentation Systems

1st Edition

ISBN:9781133478294

Author:Chatterjee

Publisher:Chatterjee

Chapter20: Medical Safety

Section: Chapter Questions

Problem 2RT

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Gain of Function research, defined as: "medical research that genetically alters an organism in a way that may enhance the biological functions of gene products." The worry is that this type of research will lead to the release of dangerous viruses and is unethical; others believe it is necessary to treat future pandemic is Gain of Function research unethical? Why?
Related top medical coding, what type of code(s) is/are specific to the disease? ICD 9 ICD 10 Procedure codes CPT codes
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Koch's postulates is useful in describing diseases. True or false
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Should he go ahead and enroll on the chance that he would receive the DNA vaccine and that it would be more effective than chemotherapy? Bruce and his parents moved to a semi-tropical region of the United States when he was about 3 years old. He loved to be outside year-round and swim, surf, snorkel, and play baseball. Bruce was fair-skinned, and in his childhood years, was sunburned quite often. In his teen years, he began using sunscreens, and although he never tanned very much, he did not have the painful sunburns of his younger years. After graduation from the local community college, Bruce wanted an outdoor job and was hired at a dive shop. He took people out to one of the local reefs to snorkel and scuba dive. He didnt give a second thought to sun exposure because he used sunscreen. His employer did not provide health insurance, so Bruce did not go for annual checkups, and tried to stay in good health. In his late 20s, Bruce was injured trying to keep a tourist from getting caught between the dive boat and the dock. He went to an internist, who treated his injury and told Bruce he was going to give him a complete physical exam. During the exam, the internist noticed a discolored patch of skin on Bruces back. She told him that she suspected Bruce had skin cancer and referred him to a dermatologist, who biopsied the patch. At a follow-up visit, Bruce was told that he had melanoma, a deadly form of skin cancer. Further testing revealed that the melanoma had spread to his liver and his lungs. The dermatologist explained that treatment options at this stage are limited. The drugs available for chemotherapy have only temporary effects, and surgery is not effective for melanoma at this stage. The dermatologist recommended that Bruce consider entering a clinical trial that was testing a DNA vaccine for melanoma treatment. These vaccines deliver DNA encoding a gene expressed by the cancer cells to the immune system. This primes the immune system to respond by producing large quantities of antibodies that destroy melanoma cells wherever they occur in the body. A clinical trial using one such DNA vaccine was being conducted at a nearby medical center, and Bruce decided to participate. At the study clinic, Bruce learned that he would be in a Phase Ill trial, comparing the DNA vaccine against the standard treatment, which is chemotherapy, and that he would be randomly assigned to receive either the DNA vaccine or the chemotherapy. He was disappointed to learn this. He thought he would be receiving the DNA vaccine.
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