A woman who sought genetic counseling is found to be heterozygous
for a chromosomal rearrangement between the second and
third chromosomes. Her chromosomes, compared to those in a
normal karyotype, are diagrammed on the next page:
(a) What kind of chromosomal aberration is shown?
(b) Using a drawing, demonstrate how these chromosomes
would pair during meiosis. Be sure to label the different
segments of the chromosomes.
(c) This woman is phenotypically normal. Does this
surprise you? Why or why not? Under what circumstances
might you expect a
rearrangement?
The woman in above problem has had two miscarriages. She
has come to you, an established genetic counselor, with these
questions:
(a) Is there a genetic explanation of her frequent miscarriages?
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