Progesterone is a steroid hormone (also described as a ligand) that prepares the bodyfor pregnancy. It binds to the progesterone receptor (PR) protein in the cytoplasm ofvarious cells.Ligand bound PR acts as a transcriptional activator, binds to the DNA in thepromoter region of several genes and leads to transcriptional activation of thesegenes.Ligand bound PR has been shown to increase the expression of a gene, FKBP5.You are studying the activity of wild-type (WT) and mutant PR in cells by examiningexpression of FKBP5. Results are obtained as shown in the figure below, where theasterisk indicates when progesterone was (or was not) added to the cells.From the results, which of the following statements can be concluded?WT PR without progesteroneWT PR with progesteroneTimeTimemutant PR without progesteronemutant PR with progesteroneTimeTimeThe wild-type PR is unable to increase FKBP5 expression in the absence ofligandThe wild-type PR increases FKBP5 expression after ligand bindingThe mutant PR shows no increase in FKBP5 expression on ligand bindingThe mutant PR is constitutively active, independent of ligand bindingFKBP5 gene expressionFKBP5 gene expressionFKBP5 gene expressionFKBP5 gene expression

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Description: Progesterone is a steroid hormone (also described as a ligand) that prepares the bodyfor pregnancy. It binds to the progesterone receptor (PR) protein in the cytoplasm ofvarious cells.Ligand bound PR acts as a transcriptional activator, binds to the

Progesterone: It is an endogenous, steroid, and sex hormone that plays an important role in the…

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From the results, which of the following statements can be concluded? FKBP5 gene expression WT PR without progesterone FKBP5 gene expression WT PR with progesterone

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter10: From Proteins To Phenotypes

Section: Chapter Questions

Problem 13QP: Suppose that in the formation of phenylalanine hydroxylase mRNA, the exons of the pre-mRNA fail to...

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Progesterone is a steroid hormone (also described as a ligand) that prepares the body for pregnancy. It binds to the progesterone receptor (PR) protein in the cytoplasm of various cells. Ligand bound PR acts as a transcriptional activator, binds to the DNA in the promoter region of several genes and leads to transcriptional activation of these genes. Which of the following statements must be true for the PR protein? O Ligand binding to the PR results in a conformational change in the primary structure of the protein The domain/region of the PR protein that interacts with the DNA, has basic amino acids Ligand binding to the PR results in a conformational change in the tertiary structure of the protein The domain/region of the PR protein that interacts with the DNA, has acidic amino acids
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