Filled-in symbols in the pedigree that follows designate individuals who are deaf. a. Study the pedigree and explain how deafness is being inherited. b. What is the genotype of the individuals in generation V? Why are they not deaf? III IV V 3 3 6 **000105000 8 9 10 11 12 13 3 4
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- Cystic Fibrosis (CF) is an autosomal recessive condition. Therefore, heterozygous (Cc) carriers do not display symptoms. Two parents who are carriers plan to start a family and you are a genetic counselor helping to advise them about their chances of having children affected by CF. a) Suppose the couple has 4 children, each one year apart. What is the probability that all 4 children will inherit CF? b) What is the probability that any 3 of their 4 children will not inherit CF, but 1 will be affected? c) What is the probability that their first child will not inherit CF, but the younger 3 children will inherit CF?2. Hemophilia is an X linked recessive trait. There is a woman who is a carrier for hemophilia and marries a man with hemophilia. a) Complete the Punnett Square (it is a google drawing so you will have to double click it to go to the drawing and type in and around the square. Hold the CONTROL (or Command) button and press the PERIOD button to write a superscript/exponent.) b) What are the possible genotypes of the children? c) Could any of their children have hemophilia? If so, would the child be male or female? Explain your reasoning.1. The pedigree chart in Figure 5.29 shows the inheritance of haemopiu family. Study the pattern of inheritance in the pedigree chart, and then answer the questions that follow. о 5 6. 3 8 9 10 11 Key Unaffected male Haemophiliac male О Unaffected female Fig. 5.29 Pedigree chart of a family affected by haemophilia a) What is the genotype and phenotype of individuals 2 and 4? b) (i) How many of the unaffected family members are definitely carriers of the recessive allele? (ii) How are you able to tell which of the family members are carriers? (4) (1) (3) c) (i) If Individual 11 marries a carrier female, what percentage of their sons is likely to be haemophiliacs? (1) (ii) Use a genetic diagram to show how you worked out your answer in i, (6) 2. Why is haemophilia never passed from father to son, even though it is most common in males? (4) 3. Can a mother pass on a sex-linked gene to her daughter? (1) 4. Sipho has red-green colour blindness. One of his grandfathers was also. colour…
- Consider the pedigree below of a dominant autosomal trait. Which individual must be non-penetrant? Select all that apply. I-1 T-2 I-1I-2 13 I-4 II-5 III-3 IV-1 IV-2 IV-3 III-2 1-2 Il-5 IIl-1 [V-2 IV-1. IV-3 Il-4In a paternity suit, a woman with type O blood claims that a man with type AB blood is the father of her type O baby. List the genetypes of the mom, man, and baby. Can the woman prove he is the father or can he is not? Why or why not? If the accused man was type A insyead of type AB, what would be his possible genotypes? Could the woman prove he is the father? Can the man prove he is not the father? Why or why not?The pedigree shows inheritance of an autosomal recessive disease in an extended family. Assume unrelated individuals marrying into the family do not carry the disease, unless there is reason to believe otherwise. What is the chance that IV-3 and IV-4 will have a child with the disease? Individuals I-1, Il-5, III-5 and III-16 have the disease. 2 1 7. III-18 2 3 5 6 17 8. 9 10 11 12 13 14 15 16 17 III-19 IV IV-3 IV-4 IV-5 IV-6 IV-1 IV-2 O a. 1/8 b. 1/12 C. 1/16 d. 3/16 e. 1/24 f. 1/32 g. 3/32 h. 1/64 FEB 17 MacBook Air 6, ... 5. %D
- Construct pedigree charts using the inheritance of hemophilia in figure 92 (page 113). This is X-linked inheritance so you are required to label XX for females and XY for males. The gene responsible for the trait is represented by the superscript which should be specified in the legend.In a paternity case a single mother claimed that a certain man was the father of her baby. The man denied it claiming that her current boyfriend was the father. The court ordered a blood test (cheaper than dna testing) to see if he could be ruled out as the father. The mother is type O and the baby was type O the man was type AB. What is the possible genotype of the biological father? A. Heterozygous Type A B. Homozygous Type A C. Heterozygous Type B15. The following pedigree shows inheritance of Huntington's disease, a fatal genetic disorder that causes neurodegeneration. Since signs and symptoms usually do not appear until adulthood, many who are carriers may not realize their risk of passing on the disease-causing allele. The following pedigree represents a family in which some people are affected by Huntington's disease. Reeessive Trit er btmnt be Mec yplicalty Hinhetee
- Consider a couple: a woman who is homozygous for a recessive mutation that causes X-linked colorblindness, and a man with full color vision (he does not carry a copy of the mutation). a) What is the probability that a son of this couple will be colorblind? b) What is the probability that a daughter of the couple will be colorblind?In man, muscular dystrophy is a condition in which the muscles waste away during early life and may result in a shorter life expectancy. It is due to a sex-linked, recessive gene. A certain couple has five children – three boys (ages 1yr, 3yrs, and 10yrs old) and two girls (ages 5yrs and 7yrs old). The oldest boy shows the symptoms of this disease. You are their family physician and they come to you for advice. What would you tell them about the chances of their other children developing the disease?What the grandparents' genotypes are? Why doesn’t the father (II-1) have the disease breast cancer? What is the formal name for an individual having the gene but not showing the trait? For this particular family, what is the recombination rate between the D17S74 marker and the breast cancer gene?