Factors influencing drug binding to plasma proteins and tissue reservoirs.  Distribution of drugs into special body compartments, e.g. role of the blood-brain barrier, placenta, etc.  Relationship of drug metabolism to excretion of drugs and termination of drug effects.

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Substance Abuse

Substance abuse refers to the use of illegal drugs in excessive quantities, as well as the misuse of legal substances such as prescription or over-the-counter pharmaceuticals or alcohol for purposes other than those intended. Drug addiction, also known as substance use disorder, is a disease that affects the brain and behavior of a person. It leads to a failure to control the use of any drug or prescription, legal or illegal.