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Draw the structure of the EISTL peptide at physiological pH. b On your structure for part (a, CIRCLE the coplanar atoms in only one peptide bond. c. On your structure for part (a), BOX two hydrogen bond donors and STAR two hydrogen bond acceptors.

Draw the structure of the EISTL peptide at physiological pH. b On your structure for part (a, CIRCLE the coplanar atoms in only one peptide bond. c. On your structure for part (a), BOX two hydrogen bond donors and STAR two hydrogen bond acceptors.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Name Shown to the right is a cartoon image of ETC Complex I from Y. lipolytica. A group of authors studied this wild type Complex I and also a version where the arginine at position 121 in the chain 3 subunit was mutated to a methionine (R121M).
Transcribed Image Text:Name Shown to the right is a cartoon image of ETC Complex I from Y. lipolytica. A group of authors studied this wild type Complex I and also a version where the arginine at position 121 in the chain 3 subunit was mutated to a methionine (R121M).
Part of chain 3 subunit contains the peptide sequence EISTL. Draw the structure of the EISTL peptide at physiological pH. a. b On your structure for part (a, CIRCLE the coplanar atoms in only one peptide bond. On your structure for part (a), BOX two hydrogen bond donors and STAR two hydrogen bond с. acсeptors. d. Calculate the pl for EISTL. е. Draw the titration curve for the EISTL peptide. f. Mark all pKa's and the pl on our curve. For the EISTL peptide at physiological pH, explain what types of interactions you believe the side chains are or are not able to participate in. g.
Transcribed Image Text:Part of chain 3 subunit contains the peptide sequence EISTL. Draw the structure of the EISTL peptide at physiological pH. a. b On your structure for part (a, CIRCLE the coplanar atoms in only one peptide bond. On your structure for part (a), BOX two hydrogen bond donors and STAR two hydrogen bond с. acсeptors. d. Calculate the pl for EISTL. е. Draw the titration curve for the EISTL peptide. f. Mark all pKa's and the pl on our curve. For the EISTL peptide at physiological pH, explain what types of interactions you believe the side chains are or are not able to participate in. g.
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