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Fundamentals Of Analytical Chemistry

Fundamentals Of Analytical Chemistry

9th Edition

ISBN:9781285640686

Author:Skoog

Publisher:Skoog

Chapter21: Potentiometry

Section: Chapter Questions

Problem 21.22QAP

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V6

Diclofenac acid has low aqueous solubility (and thus is formulated as diclofenac
sodium. It is desired to prepare a solution of 10 mM diclofenac sodium in water. Can
this be done at pH 7.0? At what pH is the maximum solubility observed?
Data: pKa =5.47
Diclofenac acid solubility, Sa = 0.241 mM
Diclofenac sodium solubility, Sa' = 65 mM

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