hapter 21[References)^ constriction of bronchial tubes.Cromolyn sodium is synthesized in the above series of steps.1. Treatment of one mole of epichlorohydrin with two moles of 2,6-dihydroxyacetophenone in the presence of base gives I.2. Treatment of I with two moles of diethyl oxalate in the presence of sodium ethoxide gives a diester II.3. Saponification of the diester with aqueous NaOH gives cromolyn sodium.Draw curved arrows to show the movement of electrons in this step of the reaction mechanism.Arrow-pushing InstructionsHOHOH3C.:AH3C.H-A:0-H:0::0:Submit AnswerTry Another Version1 item attempt remaining11:25 F31%4/20/20 HOHO.OHbaseCIEIO-C-OEtepichlorohydrinOHNaOEt2,6-dihydroxy-acetophenone*Na O2C..CO2 Na*NaOH, H2OIIOHCromolyn sodiumCromolyn sodium, developed during the 1960s, has been used to prevent allergic reactions primarily affecting the lungs, as, for example, exercised-induced emphysema. It is thought to block the release of histamine, which prevents the sequence of events leading to swelling, itching, andconstriction of bronchial tubes.v Cromolyn sodium is synthesized in the above series of steps.rch31%11:24 P4/20/20-

In any reaction bond making and breaking takes place and move ment of electron is found .

constriction of bronchial tubes. Cromolyn sodium is synthesized in the above series of steps. 1. Treatment of one mole of epichlorohydrin with two moles of 2,6-dihydroxyacetophenone in the presence of base gives I. 2. Treatment of I with two moles of diethyl oxalate in the presence of sodium ethoxide gives a diester II. 3. Saponification of the diester with aqueous NaOH gives cromolyn sodium. Draw curved arrows to show the movement of electrons in this step of the reaction mechanism. Arrow-pushing Instructions HO HO :A H-A H3C. :o: :0-H :o: :ö:

constriction of bronchial tubes. Cromolyn sodium is synthesized in the above series of steps. 1. Treatment of one mole of epichlorohydrin with two moles of 2,6-dihydroxyacetophenone in the presence of base gives I. 2. Treatment of I with two moles of diethyl oxalate in the presence of sodium ethoxide gives a diester II. 3. Saponification of the diester with aqueous NaOH gives cromolyn sodium. Draw curved arrows to show the movement of electrons in this step of the reaction mechanism. Arrow-pushing Instructions HO HO :A H-A H3C. :o: :0-H :o: :ö:

Introduction to General, Organic and Biochemistry

11th Edition

ISBN:9781285869759

Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Chapter20: Carbohydrates

Section: Chapter Questions

Problem 20.82P

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