Column A Column B 1. expresses CCR7 and has a low threshold for activation a. naive T cell b. Трн сеll 2. potentially cytotoxic and bears IL-7 receptor c. central memory Тcell (TCM) 3. expresses CD45RA and has a high threshold for activation d. memory CD8 T cell e. effector memory Тcell (TEM) 4. lacks L-selectin and CCR7 and recirculates to non-lymphoid tissues 5. participates in efficient cognate interactions with memory B cells
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Match the cell type in column A with its description in column B.
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- In the serum of 80-90% of patients with myasthenia gravis, you would expect to seeA: constitutively activated cytotoxic T cellsC: antibodies against muscarinic receptorsD: antibodies against Nm type receptorsE: antibodies against Nn type receptors1. Which of the following statements about CD4+ Th17 cells are true? i. Cannot form T effector memory (TEM) T cell populations ii. Require the master transcription factor RORgammaT for their development iii. Produce effector cytokines IL-17 and IL-22 which help recruit neutrophils and stimulate antimicrobial peptide production iv. Do not require the transcription factor NFAT for IL-2 production downstream of TCR activation v. Important for defense against intracellular bacterial infection only a. i and iii b. ii and v c. ii and iii d. ii, iii, iv e. i, ii, and ivActivation of which of the following do not cause phagocytosis to occur O Pattern Recognition Receptors O Fc Receptors O B-Cell Receptor T-Cell Receptor
- Which of the following is NOT a involved in the CD8-T-cell killing of viral-infected cells? Select one: a. Recognition of the MHC Class I and viral-derived peptide on the surface of the target cell Ob. Reorientation of the intracellular cytoskeleton to move the cytotoxic granules toward the SMAC c. Release of perforin and granzymes onto the infected target cell Od. Induction of apoptosis in the target cell by cleaving the nuclear DNA. e. Costimulation of CD8-T-cells with CD28/B71. usually, what type of molecules are present in the peripheral SMAC? 2. usually, what type of cell is on the other side of the T-cell synapse?CD1-restricted α:β T cells respond to lipid antigens of mycobacterial pathogens using all except which of the following? a. CD1a b. CD1b c. CD1c d. CD1d.
- Which are with Helper T-cells? Select all that apply. 7 CD4 0 CD8 O Release perforin O Exogenous antigen processing M Secrete IL-2 O Endogenous antigen processing O Secikte granzymes O Recognize MHC-Il molecules - Eliminate intracellular pathogens O The primary cell type that the HI-virus infects O Antigen must be presented to a Helper T-cell by an APCWhich of the flollowing reasons DOES NOT account for the barrier protective effect of IL-22? Students, this question was not on your reading, but you should be able to answer correctly. O stimulates cell survival and prliferation O stimulates synthesis of antimicrobilas like defensins etc prevents neuro-immune cross tqalk takes effect on stromal and epithelial cellsHelper T cells can be activated by macrophages(which engulf everything indiscriminately) or by B cells (which only engulf antigens that stick to their receptors). A. What properties so macrophages and B cells have ibn common that allows them both to activate T cells? B. It has been suggested that macrophages probably do most to fhte T cell activating in the primary response but B cells do most of it in the secondary response. Why does this make sense?
- MHC moleculesa. are glycoproteins.b. attach to the plasma membrane.c. have a variable region that can bind to foreign antigens andself-antigens.d. may form an MHC-antigen complex that activates T cells.e. All of these are correct.A. Organism that causes diseaseB. Larger in children than adults, this organ is the site of T cell maturation.C. Small region of substance or organism that binds directly to antibody.D. With granules that take up acidic stains, these white blood cells defend against parasites.E. Star-shaped cells critical for T-cell activationF. One type of complement pathwayG. These molecules "show off' self or non-self-peptides to T cells.H. A protein fragment that tags cells for destruction by phagocytesI.Substance or organism that induces an immune response.I.May be released into circulation or serve as a B cell receptor.K. Signalling molecule made by virally infected cells.L. The most abundant white cells in the blood, these phagocytic cells have multilobed nucleiM. A laboratory procedure that can test for antigen or antibody.N. A remarkable intracellular complex that amplifies the innate immune responseO. Receptors that recognize pathogen products and cause macrophages to produceinterleukins.P. A…Which of the following is a TRUE statement regarding the effect of high doses of corticosteroids, such as dexamethasone, on the imnune system? O None of the statements apply Functions to inhibit IgG secretion from autoimmune B cells O Functions to specifically inhibit cyclooxygenase-2 (COX-2) to decrease pain and inflammation Functions to inhibit enzyme phospholipase A2, which causes lethal disruption of WBC function (WBC death) OFunctions to inhibit enzyme phospholipase A2, which decreases cyclooxygenase- 2 (COX-2) levels