Coenzyme A (abbreviated CoA, HS-CoA, or CoA-SH) is one of the major coenzymes that play a central role in metabolic pathways. An important role of coenzyme A is to prepare molecules containing acyl group (R-CO-) for reactions with enzymes by forming a thioester bond with them as shown in the following box: Alkyl group O Thiol group R-C-OH+ HS-CoA Acyl group Coenzyme A Acyl CoA synthetase +ATP-R-C-S-CoA+AMP+PP Acyl CoA Thioester bond Deduce the missing product for the following reaction involving coenzyme A. CH₂-CH₂-CH₂-C-OH + HS-CoA + ATP Acyl COA synthetase ? +AMP+ PP₁
Coenzyme A (abbreviated CoA, HS-CoA, or CoA-SH) is one of the major coenzymes that play a central role in metabolic pathways. An important role of coenzyme A is to prepare molecules containing acyl group (R-CO-) for reactions with enzymes by forming a thioester bond with them as shown in the following box: Alkyl group O Thiol group R-C-OH+ HS-CoA Acyl group Coenzyme A Acyl CoA synthetase +ATP-R-C-S-CoA+AMP+PP Acyl CoA Thioester bond Deduce the missing product for the following reaction involving coenzyme A. CH₂-CH₂-CH₂-C-OH + HS-CoA + ATP Acyl COA synthetase ? +AMP+ PP₁
Chapter21: Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions
Section21.SE: Something Extra
Problem 41MP
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