When the compound I is replaced by compound II for anti-fungal activity, it was found that II has less side effects on the central nervous system (CNS) compared to I. The most likely explanation is: CI N. OH .CI II O The sulfur containing ring in I was easily converted into a toxic metabolite by the enzymes present in the CNS. O Replacement of Cl atoms by F leads to higher solubility in body fluids. O Il is more polar than I, hence it cannot cross the blood brain barrier easily. O The triazole rings in II is more bioorthogonal

When the compound I is replaced by compound II for anti-fungal activity, it was found that II has less side effects on the central nervous system (CNS) compared to I. The most likely explanation is: CI N. OH .CI II O The sulfur containing ring in I was easily converted into a toxic metabolite by the enzymes present in the CNS. O Replacement of Cl atoms by F leads to higher solubility in body fluids. O Il is more polar than I, hence it cannot cross the blood brain barrier easily. O The triazole rings in II is more bioorthogonal

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter19: Aldehydes And Ketones: Nucleophilic Addition Reactions

Section19.SE: Something Extra

Problem 29VC

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