Chemical X is a contaminant present in low quantities in drinking water. Its molecular size is abo nm and it may bind briefly with plasma albumin. Chemical X is a weak base with a pka of 5. Assuming the pH of the stomach is 1, the pH of the blood is 8, and the pH of the small intestine is 8.5, describe the absorption, distribution, biotransformation and excretion of Chemical X in a human.
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- Use a calculation based on the pH partition model to determine the likelihood that a weakly acidic drug of pKa= 3.0 will be absorbed passively from the stomach (pH = 2.3) or from the small intestine (pH = 5.0). The pH of the blood is 7.4 .Normal arterial pH is 7.35 to 7. 45. Both metabolic and respiratory alkalosis have pH more basic compare to the normal arterial pH. The difference is 0.5 units. What is pH value in alkalosis? Niemann-Pick type C disease is a progressive neurological disease; symptoms include unsteady walking with uncoordinated limb movements, slurred speech, a difficulty in swallowing, epilepsy and tremor. This condition is due to the abnormal functioning of a lysosome. State the normal functions performed by this organelle.In a hospital laboratory, a 10.0 mL sample of gastric juice, obtained several hours after a meal, was titrated with 0.01 M NaOH to neutral pH of 7.0; 72.0 mL of NaOH was required for this titration. The patient’s stomach contained no ingested food or drink, thus assume that no buffers were present. What was the pH of the 10.0 mL gastric juice sample before titrating with NaOH?
- It is recommended that children should have fluoride supple- ments for their teeth if the fluoride content of drinking water is 0.7 ppm or less. How much is this when expressed as a concentration of micrograms per litre?calculate the amount of that food that you would need to ingest for it to be fatal to a human assuming there is a 5 l of blood in the human body is this an amount that you need to be concerned about? explain amount needed: 5ml Final pH: 5.8You receive a prescription for Epanutin® Suspension. The patient normally takes 150mg daily in capsule form, however he has recently started to have difficulty in swallowing them. The doctor asks you to check that the Epanutin® Capsules and Suspension are equivalent to each other. The following information is extracted from the BNF. Dose equivalence and conversion Preparations containing phenytoin sodium are not bioequivalent to those containing phenytoin base (such as Epanutin® suspension); 100 mg of phenytoin sodium is approximately equivalent in therapeutic effect to 92 mg phenytoin base. Epanutin 30mg/5ml oral suspension (Pfizer Ltd) Phenytoin 6 mg per 1 ml Phenytoin sodium 100mg capsules (Actavis UK Ltd) Phenytoin sodium 100 mg What daily dose of Epanutin® Suspension should be written on the dispensing label (in ml)? (Round to the nearest ml) units -ml
- You are supplied with the following: / Jy word voorsien van die volgende: NaCl (Mr= 58,443 g /mol) 2.5M Tris-Cl, pH 8 solution /oplossing (1 Litre) EDTA (Mr= 380,2g/mol) 10% sodium dodecyl sulphate solution / natriumdodecyl sulfaat oplossing Proteïnase K solution / oplossing (50 mg dissolved / opgelos in 1 ml ddH2O) You need a digestion buffer consisting of the following: / Jy moet 'n verteringsbuffer op maak wat uit die volgende bestaan: 15m M NaCl 75 mM Tris-Cl,pH 8 16 mM EDTA,pH 8 0.8% sodium sulphate / natrium dodecyl sulfaat 0,75 mg/ml proteïnase K How will you prepare 500 ml of the digestion buffer? Show all your steps and calculations. Remember to explain exactly how you will make it up. / Hoe sal jy 500 ml van die verteringsbuffer voorberei? Wys al jou stappe en berekeninge. Onthou om te verduidelik presies hoe jy dit sal op maak.A 38-year old man was admitted with a 3-day history of severe diarrhea with some nausea and vomiting. During this period his only intake was water. He was weak, unable to stand and when recumbent his pulse was 106/minute and blood pressure was 110/50 mmHg. On admission, his biochemistry results were: Analyte Result Reference range Na+ 129 135-145 mmol/l K+ 2.9 3.5-5.0 mmol/l Cl- 85 95-105 mmol/l HCO-3 18 21-28 mmol/l Urea 19 2.5-8.0 mmol/l Creatinine 160 40-130 mmol/l 2. What is the most appropriate treatment for this patient and comment on the patient’s results 3. Briefly explain the various types fluid spacing 4. A 27-year old man is admitted to Sunyani regional hospital with a week long history of severe vomiting. He appeared clinically severely dehydrated with shallow breathing. Initial biochemistry results were: Analyte Result Reference range Arterial blood gases H+ 27 35-45 mmol/l…Muzolimine is a diuretic. Pure muzolimine (mp 127-129°C) is a crystalline solid at room temperature. Nifenazone is an analgesic. Pure nifenazone (mp 252-253°C) is a crystalline solid at room temperature. Which one of the following statement is correct? O A melting point of 212-217°C is consistent with a sample of nifenazone contaminated with a small quantity of muzolimine O A melting point of 212-217°C is not consistent with a sample of nifenazone contaminated with a small quantity of muzolimine
- Refer to the following titration curve below: 13 12 11 10 7 5 4 3 2 8 10 12 14 16 18 20 22 24 26 28 30 Volume of Titrant / mL Unknown Acid 0.10 mol/L - titrant = NaOH 0.1 mol/L How many buffering regions are present in the titration curve of the amino acid?At what pH does a lysine solution exhibit the highest buffering capacity? (Lysine pKas: pk1 = 2.2, pK2 = 8.95, pK3 = 10.5) %3D O рH 12.1 О рH 9.72 O pH 5.67 pH 8.95Calculate the unknown concentration of the PROTEIN C with an absorbance value of A412 given the standard curve indicated in the table below. Write your final answer (NUMBER ONLY) in two decimal places rounded off. Protein concentration (µg/mL) 0 0.02 0.04 0.06 0.08 0.10 Your answer APIENT Absorbance 0.000 0.161 0.284 0.438 0.572 0.762