CASE STUDY: History and Physical Examination This 6-year-old white male patient was taken to a pediatrician because of recurring abscesses since the age of 1 month. The current abscesses were lanced, and he was placed on antibiotic therapy. The patient had two brothers who had died in infancy of infections. His parents and two sisters are healthy. Laboratory Data Hemoglobin and hematocrit-slightly decreased Total leukocyte count-elevated Differential leukocyte count-increased percentage of segmented neutrophils Immunoglobulin profile-polyclonal elevation of all lg classes Neutrophil oxidative burst assay (DHR) activity absent Nitroblue tetrazolium (NBT) test (automated)-reduction of unstimulated and stimulated neutrophils Culture of abscess revealed S. aureus Guide Questions: 1. Based on the laboratory data, what is your primary impression? 2. What does the patient's family history suggest? - A genetic disorder in male offspring or X-linked CGD. 3. What are the significant data/information based on the history of the patient? Why? 4. What does the neutrophil oxidative burst activity assay indicate? 5. What enzyme is defective in this disease? What is it used for? 6. What is the cause of the recurrent abscesses of the patient? Discussions 1. What are the different Congenital Neutrophil Abnormalities? Briefly discuss each.

Essentials of Pharmacology for Health Professions

7th Edition

ISBN:9781305441620

Author:WOODROW

Publisher:WOODROW

Chapter25: Cardiovascular Drugs

Section: Chapter Questions

Problem 3CRQ

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Transcribed Image Text:CASE STUDY: History and Physical Examination This 6-year-old white male patient was taken to a pediatrician because of recurring abscesses since the age of 1 month. The current abscesses were lanced, and he was placed on antibiotic therapy. The patient had two brothers who had died in infancy of infections. His parents and two sisters are healthy. Laboratory Data Hemoglobin and hematocrit-slightly decreased Total leukocyte count-elevated Differential leukocyte count-increased percentage of segmented neutrophils Immunoglobulin profile-polyclonal elevation of all lg classes Neutrophil oxidative burst assay (DHR) activity absent Nitroblue tetrazolium (NBT) test (automated)-reduction of unstimulated and stimulated neutrophils Culture of abscess revealed S. aureus Guide Questions: 1. Based on the laboratory data, what is your primary impression? 2. What does the patient's family history suggest? - A genetic disorder in male offspring or X-linked CGD. 3. What are the significant data/information based on the history of the patient? Why? 4. What does the neutrophil oxidative burst activity assay indicate? 5. What enzyme is defective in this disease? What is it used for? 6. What is the cause of the recurrent abscesses of the patient? Discussions 1. What are the different Congenital Neutrophil Abnormalities? Briefly discuss each.

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