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- Draw a Punnett square for the dihybrid cross described below (it is the same story as given for question 8, above) and use it to fill in the blanks correctly in the text that follows. NOTE: Please type in whole numbers, no symbols. There are two known alleles of gene occupying a specific locus in the X chromosome. The gene in question codes for a transcription factor involved in digit development. The mutant allele is dominant and gives rise to an additional but non-functioning little finger (polydactyly) on both hands. A couple have had their DNA sequenced at the region of interest, the male exhibits polydactyly because of the mutation, the female is homozygous wild type at the same locus and therefore has the wild type phenotype. Both have green eyes. In this story; eye colour shows a monogenic autosomal inheritance pattern and the allele for brown eyes shows incomplete dominance with that for blue eyes, the heterozygote phenotype is green eyes. The genes for eye colour and…tate. edu/d21/le/content/5003190/viewContent/44248878/View 10. The genes Stubble (Sb), Lyra (Ly), and bright (br) are all linked on chromosome 3 in Drosophila fruit flies. An organism that was heterozygous for all three genes was mated to an organism that was homozygous recessive for all three. The following phenotypes were seen in the offspring: All wild-type 422 Lyra and Stubble 4. Stubble and bright 16 Lyrà and bright 75 Lyra only 18 Stubble only 59 Bright only Lyra, Stubble, and bright 404. f. What are the alleles in the parental gametes?Shown above is a family pedigree tree in which family members afflictedwith the disease Haemophilia are shown with filled-in squares (male) or circles (females). A couple is trying to determine the likelihood of passingon the disease to their future children (represented by the ? symbolabove) because the hemophilia runs in the woman’s family. Turner syndrome is a disease in which an individual is bornwith only a single X chromosome. Suppose the woman in thecouple is a carrier for hemophilia and has a child with Turnersyndrome. Would this child have the disease?
- Answer the following questions given the pedigree below. Please assume that no other mutations are occurring, complete penetrance, and that the individual marked with an asterisk (*) doesn’t carry the allele causing the affected phenotype. Q4) Assuming II-2 and II-3 want to have another child. what are all the possible genotypes, and what is the percentage that their child will be affected?The following pedigree describes the inheritance of Lesch-Nyhan syndrome, an x-linked recessive disease. Affected individuals are shaded. what is the probability, that the indicated child (IV.1) will be affected by Lesch-Nyhan syndrome? show solutionSuppose gene B is X-linked and is embryonically lethal when homozygous or hemizygous recessive. A man marries a woman who is heterozygous for this gene. They want to have three kids – one girl and two boys. Using a Punnett square, answer the following: What is the probability that they will have a son that dies before birth? _______________________ What is the probability that they will have a daughter who has the same genotype as her mother? _________________ One of their daughters eventually has a child with a man. One of their sons dies before birth. What was the genotype of this daughter? _______________________________ please show me how to get the answer and explain how you got and use a punnet square
- The following pedigree shows the inheritance of a human disorder. Affected individuals are shown with filled symbols. II III 2 3 5 Based on the pedigree, propose the least likely inheritance pattern of the disease among autosomal dominance, autosomal recessive, X-linked dominance and X-linked recessive. Your choice of answer can be impossible and possible. Explain your answer by giving the evidence that supports or opposes each mode of inheritance. You can reconstruct the table shown below and draw the pedigree in your answer script. Write the possible genotype of each individual in the pedigree for each inheritance pattern proposed. Mode of Possibility Explanations Pedigree inheritance Autosomal dominance Autosomal recessive X-linked dominance X-linked recessiveA woman who sought genetic counseling is found to be heterozygousfor a chromosomal rearrangement between the second andthird chromosomes. Her chromosomes, compared to those in anormal karyotype, are diagrammed on the next page:(a) What kind of chromosomal aberration is shown?Please consider the following pedigree. Assume that people who marry in to the family do not carry the allele unless otherwise indicated. Assume complete penetrance. I II 5 6 III 6 IV 1 2 a. Is it possible for the inheritance pattern for the trait illustrated in this pedigree to be as a result of each of the following? Answer yes or no. (i) an autosomal recessive allele (AR) (ii) an autosomal dominant allele (AD) (iii) a X-linked recessive allele (XR) (iv) a X-linked dominant allele (XD) b. Provide a genotype for individual III-6 for the most likely mode of inheritance as determined in (a).
- Congenital hypertrichosis (CH) is a very rare X-linked dominant inherited condition. CH is characterized by the growth of dark hair over the body. CH is so rare, only 50 cases have been identified since the Middle Ages. The incidence of this condition is considerably higher in a small Mexican village (from which the partial pedigree below is derived) than the rest of the human population. I II III Use the following information to answer the two questions. IV D II-4 8 9 IV-6 0=10~ 11 1. Using appropriate nomenclature, identify the genotypes for the following 2 individuals: 12 13 your response must include an appropriate legend/key to identify allele symbols. 2. Show how a Punnett square (using the allele symbols from the previous question) is used to determine the probability in percent of individuals III-11 and III-12 next offspring has CH?The pedigree shows inheritance of the autosomal recessive trait cystic fibrosis in a family. Family members who are known to have the disease are represented by black shading. I 1 2 3 4 II 1 3 4 6 8 7 III 1 2 3 4 5 6 7 Part A: Select the best answer from the boxes below to indicate the likely genotypes of the following individuals, where F indicates the wild-type (usual) allele and f indicates the cystic fibrosis allele. The first part of their number (I, II or III) indicates their generation or row, whilst the second part of their number (1-8) indicates the individual within that generation or row. |-4 Il-3 Il-8 III-3Please consider the following pedigree. Assume that people who marry in to the family do not carry the allele. Assume complete penetrance. I II III 3 IV 1 2 a. Is it possible for the inheritance pattern for the trait illustrated in this pedigree to be as a result of each of the following? Answer yes or no. (i) an autosomal recessive allele (AR) (ii) an autosomal dominant allele (AD) (iii) a X-linked recessive allele (XR) (iv) a X-linked dominant allele (XD) b. Based strictly on the characteristic patterns of inheritance that define the four different options in (a), give a definitive motivation for the most likely mode of inhertance.