(b) (: ) Explain briefly whether the binding of the anesthetic gas to hemoglobin facilitates or hinders the delivery of O2 to tissues from red blood cells and on what basis do you make your conclusion.

Phlebotomy Essentials
6th Edition
ISBN:9781451194524
Author:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Publisher:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Chapter1: Phlebotomy: Past And Present And The Healthcare Setting
Section: Chapter Questions
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5. Anesthetic gases used in surgery are known to bind to the hemoglobin molecule in red blood cells.
The diagram below illustrates O2 binding curves of normal human HbA in the presence of the anesthetic
gas dichloromethane (DCM).
O UNTREATED
100
Symbols:
a Dсм 23 Torr
• DCM 50 Torr
x DCM I00 Torr
o, 0 Torr DCM;
О, 23 Torr DСМ
Д, 50 Torr DСМ
x, 100 Torr DCM.
80
60
40
(1 Torr = 1 mm Hg.)
20
The
solutions
were
buffered to pH 7.4.
0.5
1.0
1.5
2.0
log p02
For the curves at 0 and 100 Torr of dichloromethane, draw their equivalent in the form of
(a) (*
Hill plots. Label the axes and indicate on both the plot above and the Hill plot where the value of the
dissociation equilibrium constant Kd for O2 binding is defined for 0 and 100 Torr of dichloromethane
Kd
Hb(O2)n
nO2
Hb
+
Be sure to label the axes, indicate the units on both axes, and make the Hill plot so that the values of
Kd are equivalent to those on the saturation plot above. Indicate whether cooperativity, as indicated
by the Hill coefficient nH, increases or decreases with increasing partial pressure of the anesthetic gas.
(Note: This question does not require you to calculate the value of nH. It requires you to demonstrate
only in which direction it changes by showing how the Hill plot changes.)
(b) (: . ) Explain briefly whether the binding of the anesthetic gas to hemoglobin facilitates or hinders
the delivery of O2 to tissues from red blood cells and on what basis do you make your conclusion.
% OXYGENATION
Transcribed Image Text:5. Anesthetic gases used in surgery are known to bind to the hemoglobin molecule in red blood cells. The diagram below illustrates O2 binding curves of normal human HbA in the presence of the anesthetic gas dichloromethane (DCM). O UNTREATED 100 Symbols: a Dсм 23 Torr • DCM 50 Torr x DCM I00 Torr o, 0 Torr DCM; О, 23 Torr DСМ Д, 50 Torr DСМ x, 100 Torr DCM. 80 60 40 (1 Torr = 1 mm Hg.) 20 The solutions were buffered to pH 7.4. 0.5 1.0 1.5 2.0 log p02 For the curves at 0 and 100 Torr of dichloromethane, draw their equivalent in the form of (a) (* Hill plots. Label the axes and indicate on both the plot above and the Hill plot where the value of the dissociation equilibrium constant Kd for O2 binding is defined for 0 and 100 Torr of dichloromethane Kd Hb(O2)n nO2 Hb + Be sure to label the axes, indicate the units on both axes, and make the Hill plot so that the values of Kd are equivalent to those on the saturation plot above. Indicate whether cooperativity, as indicated by the Hill coefficient nH, increases or decreases with increasing partial pressure of the anesthetic gas. (Note: This question does not require you to calculate the value of nH. It requires you to demonstrate only in which direction it changes by showing how the Hill plot changes.) (b) (: . ) Explain briefly whether the binding of the anesthetic gas to hemoglobin facilitates or hinders the delivery of O2 to tissues from red blood cells and on what basis do you make your conclusion. % OXYGENATION
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