At what position, and on what ring, would you expect the following substances to undergo electrophilic substitution? Draw the structure and indicate with asterisks the expected position on the ring. Br ن
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- Denote how many nucleophilic centers are present in the following molecular structure (in case of polar bonds show clearly on the structure the dipoles õ+ and d-). :o: сноRank the following groups in order of their ability to activate an aromatic compound to electrophilic aromatic substitution.5) There are two aromatic rings in the structure. Indicate what positions an electrophile can attack and explain it with the resonance structures. CH3
- Rank the following compounds in order of increasing reactivity in a substitution reaction with −CN as nucleophile.Rank group of compounds from most reactive to least reactive toward electrophilic aromatic substitution: toluene, p-cresol, benzene, p-xyleneWhat effect and orientation does -OH group exhibit in electrophilic aromatic substitution reaction ?
- Rank the reactivity of the compounds below toward nucleophilic acyl substitution by writing the compounds' letters in the proper blanks in the box below. `NH CI Br CH3 CH3 A В C E rank compounds for acyl substitution reactivity most least reactive reactiveTamoxifen is a drug used to prevent and treat breast cancer. What are all the possible metabolic reactions for this drug? Aromatic hydroxylation Epoxidation ON-dealkylation Benzylic hydroxylation O Epoxidation followed by epoxide hydrolysisRank the following compounds in order of increasing reactivity during an electrophilic substitution reaction
- Which of the following molecules is the most reactive in an electrophilic aromatic substitution reaction?Draw the structures of all possible products formed from the following reaction. Specify the type of substitution or elimination pathway. Demonstrate the sterrochemical outcomes of the reaction by drawing your products in wedge dash form when necessary.18) The following reaction undergoes three distinct steps: imine formation, electrophilic aromatic substitution, and decarboxylation. Draw each of the intermediates from each of these three steps as well as the final product. BS NH₂ OH heat