Answer Nursing 1.1 Is there a possibility that by manipulating the microenvironment, we could disrupt the signals controlling the phenotype of cancer (stem?) cells.?
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Answer Nursing 1.1 Is there a possibility that by manipulating the microenvironment, we could disrupt the signals controlling the
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- Panswer Nursing 1.1 Is there a possibility that by manipulating the microenvironment, we could disrupt the signals controlling the phenotype of cancer (stem?) cells.?-Describe the seven hallmarks of cancer i) List the seven hallmarks ii) Connect each hallmark to the type of change -Explain importance of p53 i) Know the function of p53 ii) Explain how loss of p53 can result in several hallmarks of cancer1. Describe & explain the pathophysiology of cancer based on the diagram. Reference: https://www.onlinebiologynotes.com/cancer-etiology-pathophysiology-types-diagnosis-and- treatment/ Acquired (environmental) DNA damaging agents: • chemical • radiation viruses Activation of growth- promoting oncogenes NORMAL CELL DNA Damage Failure of DNA repair Mutations in the genome of somatic cells Alteration of genes that regulate apoptosis Malignant neoplasm / Successful DNA repair CANCER Inherited mutations: • Genes affecting DNA repair • Genes affecting cell growth Expression of altered gene products and loss of regulatory gene products Inactivation of cancer suppresor genes Clonal expansion Additional mutations (progression) T Heterogeneity
- Hi, can you elaborate about: 1. MyoD to be used to manipulate cancer cells at an early stage and then be used as a treatment. 2. Angiogenesis is a major function for tumor cells to grow, so if we break off the blood supply, would this result in better treatment?34. List and describe common manifestations of cancer? a) Local effects of tumors b) Systemic effects of malignant tumors.Tissues and differentiation a)Explain what is meant by termination and differentiation ).b) Explain the difference between an oncogenic and a tumour suppressor gene and describe how they are involved in the onset of cancer
- Lung cancer mitotic index: 0.25 Breast cancer mitotic index: 0.35 Skin cancer mitotic index: 0.4 Looking at the mitotic index for all 3 cancer types, which one is likely to be the most resistant (least affected) to the growth-inhibiting effects of traditional chemotherapy drugs that target rapidly dividing cells?Figure 17.15 In 2011, the United States Preventative Services Task Force recommended against using the PSA test to screen healthy men for prostate cancer. Their recommendation is based on evidence that screening does not reduce the risk of death from prostate cancer. Prostate cancer often develops very slowly and does not cause problems, while the cancer treatment can have severe side effects. The PCA3 test is considered to be more accurate, but screening may still result in men who would not have been harmed by the cancer itself suffering side effects from treatment. What do you think? Should all healthy men be screened for prostate cancer using the PCA3 or PSA test? Should people in general be screened to find out if they have a genetic risk for cancer or other diseases?Outline the steps that lead to a cell becoming cancerous.
- Discuss the behaviors of cancer cells that maydifferentiate their growth from that of normal cells.#1) Hyperplastic growth are not cancerous yet but show a higher than normal proliferation rate. True False #2) When cancer cells have not spread beyond its original site, the term used to describe it is benign growth intraepithelial neoplasia carcinoma stage 3 carcinoma in situ #9) Cancer cells generally have missense mutations in p53 gene, resulting in truncated p53 normally active p53 dominant negative p53 inactive p53 #10) Single or double stranded breaks in DNA activate Chk 1 and 2 kinases, which phosphorylates p53. This results in --- in the level of p53 in the cell. increase decrease1) Briefly outline the location, isolation , characterisation, benefits, and limitations of adult stem cells in TERM 2) Describe and compare the various potencies exhibited by stem cell pheno type 3) Outline the in vitro/in vivo mechanical forces that can be used to influence the quality of cell response and tissue formation obtained by TE..
