All of the following are examples of how tumors or the microenvironment in which they develop suppress immune responses except _____. a. induction of T-cell anergy b. peptide splicing of self proteins c. cleavage of MIC glycoproteins from tumor-cell surfaces d. TGF-β-induced recruitment of regulatory T cells e. release of TGF-β and IL-10 by regulatory T cells.

All of the following are examples of how tumors or the microenvironment in which they develop suppress immune responses except _____. a. induction of T-cell anergy b. peptide splicing of self proteins c. cleavage of MIC glycoproteins from tumor-cell surfaces d. TGF-β-induced recruitment of regulatory T cells e. release of TGF-β and IL-10 by regulatory T cells.

Essentials of Pharmacology for Health Professions

7th Edition

ISBN:9781305441620

Author:WOODROW

Publisher:WOODROW

Chapter14: Antineoplastic Drugs

Section: Chapter Questions

Problem 4CRQ

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The binding groove of endothelial protein C receptor (EPCR) binds to _____ and presents them to _____. a. phosphoantigens; Vγ9:Vδ2 T cells b. MIC-A or MIC-B proteins; NK cells c. sulfatides; Vγ:Vδ1 T cells d. phospholipids; Vγ4:Vδ5 T cells e. lipid antigens; Vα24–Jα18:Vβ11 NKT cells.
During the adaptive immune response, the role of helper T cells includes _____. Mark all that apply. Group of answer choices a. using CD8 to identify cells that are infected with pathogens b. facilitating clonal selection c. using CD4 to recognize antigen presenting cells d. activating mitosis in B cells e. auto-activation of mitosis (self-activating mitosis to produce more helper T and memory T cells) f.using T cell receptors to bind epitopes on pathogens
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Apoptosis is Select one: A. equivalent to necrosis. B. caused by T cell anergy. C. involved in peripheral tolerance, but not central tolerance. D. impaired in Fas-deficient systems. E. involved in central tolerance, but not peripheral tolerance. O O O O
All of the following regarding CD1a, b, and c are true except _____. a. They have a more limited tissue distribution than CD1d. b. CD1b associates with CD1e for the purpose of lipid transfer. c. They cycle through endosomal vesicles in different locations of the cell with the assistance of adaptor proteins. d. They possess different sizes of antigen-binding sites. e. They all present lipid antigens. f. They cycle continually between the cell surface and endosomal compartments, allowing exchange of antigens. g. CD1b can accommodate more than one antigen simultaneously. h. They are expressed by double-positive thymocytes and facilitate positive selection of CD1-restricted T cells. i. They present antigens to NKT cells.
HIV could be used to cure Kaposi’s sarcoma bya. causing the cells to express exogenous surface cell markersb. activating genes for the expression of endogenous surface cell markersc. inactivating the patient’s tumor suppressing genesd. inactivating contact inhibition in the celle. inactivating cellular adherence
The human immunodeficiency virus (HIV) selectively destroys TH cells. Which of the following occurs? O Loss of specific adaptive immune response due to the lack of clonal expansion Loss of a specific adaptive immune response due to the lack of mast cell function O Loss of antigen presenting cell function due to the loss of MHC II expression O All of the answers apply, no exception O Loss of a specific adaptive immune response due to the lack of MHCI expression
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Memory T cells _____. (Select all that apply.) a. must all be activated in secondary lymphoid organs b. do not require co-stimulation through CD28 c. are composed only of CD4 T cells d. do not undergo somatic hypermutation e. are usually short-lived f. do not undergo isotype switching.
All of the following are true in reference to T-cell priming except _____. a. it occurs in primary lymphoid organs b. it transforms naive T cells into differentiated effector T cells c. it is the first stage of a primary adaptive immune response d. it requires interaction between naive T cells and antigen-presenting cells e. it takes place in many locations including, but not limited to, lymph nodes, Peyer’s patches, and the tonsils.
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