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- 2. Propose a mechanism for the following reaction Br HBr3. Provide a mechanism for the following transformation: H3C. HO HCI CH3OH HC ✓ LOCH, * HO 4. Provide a mechanism for the following transformation: A NaOH H2N + H₂O, A O NaFill in the missing products below. 1) Hg(OAc)2, EtOH 2) NaBH4 Excess HI A B Heat RCO3H 1) H-CEC: Na D 1) NaSEt 2) H3O+ 2) H₂O+ → E HBr → F
- 3. Propose a mechanism for the following reaction: Br- OH NaNH, + NH3 + NaBrCome up with a detailed mechanism for the following cyclization that also includes all resonance strictures for any intermediates that form. Also, explain why the alkyl bromide portion of the molecule remains intact in the product even though the reaction conditions are strongly basic/nucleophilic. Br Br NaOMe Me Me Me Me MeOH MeO2C 0 °C MeO₂C1 Provide the reagent(s) (in the correct order) for the following: ??? H2N. OCH3 OCH3 Br `NO2 2. *y Provide the product and a stepwise mechanism for the following nucleophilic aromatic substitution reaction. Include all intermediates, resonance structures, and electron pushing arrows. If you need to redraw the structure to show electron flow please do so. OHC, CH3NH2 CI
- Show how the product formed as a result of the reaction can be synthesized using the starting materials given below. Any reagent needed can be used and you may need more than one step. c) HO, al OH d) b) Он4. Provide a mechanism for the following reaction. H₂SO4, H₂O HgSO4 enVoltooi die volgende reaksie en stel 'h meganisme voor. Complete the following reaction and propose a mechanism. 1) CO2, P, A 2) H20, H*
- 4. Predict the product and provide a mechanism for the following reaction. H3O* CNFill in the boxes with the missing products of each reaction. For box B to C, suggest a mechanism for that reaction step. EtO₂C CO₂Et NaOEt EtOH NaOEt EtOH Br H3O+ A B*Provide the product(s) of each reaction below. Label each product with the reaction mechanism that produced it (SN2/SN1/E1/E2) and point out major vs. minor elimination products. Pay attention to stereochemistry as appropriate. Br H;CO. ONa CI Nao b) CF3 Ph Br CD,OH c) Ph