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a) Which catalytic mechanism occurs in step 2? b) Why must phosphate first bind to succinyl-CoA before interacting with the His site and GDP?

a) Which catalytic mechanism occurs in step 2? b) Why must phosphate first bind to succinyl-CoA before interacting with the His site and GDP?

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Succinyl-CoA Synthetase mechanism Succinyl-CoA synthetase enzyme active site O Substrates bind to the active site COO of succinyl-CoA synthetase CH2 OH His CH2 . Succinyl-CoA COA- Guanosine Phosphoryl group transfer to GDP to form GTP, which is released from the 2 Formation of succinyl-phosphate COA GTP enzyme Formation of phosphohistidine Guanosine COO Phosphohistidine CH2 GDP GDP CH2 COO CH2 | "Succinate CH, Succinyl-phosphate ČOO a) Which catalytic mechanism occurs in step 2? b) Why must phosphate first bind to succinyl-CoA before interacting with the His site and GDP?
Transcribed Image Text:Succinyl-CoA Synthetase mechanism Succinyl-CoA synthetase enzyme active site O Substrates bind to the active site COO of succinyl-CoA synthetase CH2 OH His CH2 . Succinyl-CoA COA- Guanosine Phosphoryl group transfer to GDP to form GTP, which is released from the 2 Formation of succinyl-phosphate COA GTP enzyme Formation of phosphohistidine Guanosine COO Phosphohistidine CH2 GDP GDP CH2 COO CH2 | "Succinate CH, Succinyl-phosphate ČOO a) Which catalytic mechanism occurs in step 2? b) Why must phosphate first bind to succinyl-CoA before interacting with the His site and GDP?
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