A patient of African American decent came in due to vasooclusive symptoms, you suspect a condition that causes polymerization of the mutant hemoglobin upon deoxygenation in the tissues. a. What conditions can facilitate polymerization? b. Explain the effects of metabolic acidosis to facilitate polymerization?

Human Physiology: From Cells to Systems (MindTap Course List)
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Chapter11: The Blood
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A patient of African American decent came in due to vasooclusive symptoms, you suspect a condition that causes polymerization of the mutant hemoglobin upon deoxygenation in the tissues.

a. What conditions can facilitate polymerization?

b. Explain the effects of metabolic acidosis to facilitate polymerization?

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