A novel new method of peptide synthesis involves formation of an amide bond by reaction of an a-keto acid with an N-alkylhydroxylamine. Он R + Co2 + H20 R R' Draw curved arrows to show the movement of electrons in the following step of the reaction mechanism Arrow-pushing Instructions :0: :ö: c-ö: R H20 CO2 A R R H-A
Q: The isoelectric point (p) of the following amino acid is determined to be 5.97. H2N. OH Which of the…
A: The isoelectric point (pI) is the pH at which a particular molecule carries no net electrical…
Q: This angle reflects the free rotation around the alpha-carbon : amide nitrogen bond in the peptid…
A: A dihedral angle is the angle for polypeptide backbone where 2 adjacent planes join and the…
Q: 5. A peptide is synthesized using a solid-phase peptide synthesis strategy. Amino acids are…
A: In the given problem, the amino acids are represented by a single letter code. So, the above amino…
Q: 8. Hydrolysis of the peptide bonds in peptide below would result in Пн НзN-CHC-N-CHC-N-CНС-о CH2 Он…
A: Here two peptide bond are present , and they are formed when two amino acid react together and water…
Q: What are the alpha-amino acids (AA1, AA2, AA3) needed to complete the following synthesis?…
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Q: What is C terminal amino adid of the peptide below? OH N. OH H;N N. H. H. Select one: a. H,N-CH HN-…
A: The structure of an amino acid and peptide bond is as follows:
Q: Tyrosine is one of the natural amino acids; it acts as an electron donor in the reduction of…
A: Since the bond angle 1 is shown with the centre atom carbon And we can see that the carbon is…
Q: Which of the following statements correctly describe the peptide bond hydrolysis reaction? [Select…
A: We have to predict the correct statement about peptide hydrolysis.
Q: Rank these basicities of the amine groups in these amino acids according to their expected pK,…
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Q: Isoleucine is among the twenty amino acids found naturally in the human body. Assign R or S…
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Q: Glycine has pKa values of 2.34 and 9.60. At what pH does glycine exist in the indicated form?
A: The first set of structures is a 50:50 mixture. The 50% of amino group of the glycine are released…
Q: 1. Draw the bond-line structure showing the zwitterionic form of each of the following amino acids:…
A: As per our guidelines we are supposed to answer only one question. Kindly repost other questions as…
Q: 4. Write out the 1° structure for the following polypeptide: Ο Η ОН H₂N-CH-C-N-CH-C-N-CH-COO T CH-OH…
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Q: Calculate the isoelectric point for each amino acid.a. cysteine: pKa (COOH) = 2.05; pKa (a-NH3+) =…
A: The formula used to calculate the isoelectronic point is,
Q: Cisplatin preferentially binds N' of the purines adenine and guanine. Draw the product of the…
A: The correct answer is given below
Q: 4. Circle all of the peptide bonds in the molecule below. Write the name of the molecule using the…
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Q: 3. If D-serine has a specific activity of +6.83, what will be the specific activity if it is…
A: The specific activity of enantiomers are equal in magnitude but they have opposite signs because…
Q: The side chain of acetyl-L-lysine-OMe has a pKa=10.5 and its acid-dissociation reaction is shown…
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Q: 5-Bromouracil (BU) resembles thymine sufficiently that BU base-pairs readily with adenine in a DNA…
A: 5 bromo uracil is an analog of thymine. It resembles thymine in structure and can be incorporated in…
Q: 3. Below are the structures for leucine and tyrosine. H. *H3N-c-coo- "HN-C-COo- CH2 leucine HĆ CHs…
A: “Since you have asked multiple question, we will solve the first question for you as per our…
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Q: αcarboxyl and α-amine are 2.2 and 9.1 perspectively. Calculate isoelectric point of tyrosine. i want…
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Q: Glycine has pKa values of 2.34 and 9.60. At what pH does glycine exist in the indicated form?
A: The given structures is a 50:50 mixture.
Q: 7. The structure of the amino acid alanine is C- COOH H Give the structural formula of the species…
A: The chemical species that contain an amino group and a carboxylic acid group on the same carbon atom…
Q: opy of The following reaction scheme shows the states of the amino acid hisitdine. Histidine has…
A: When pH > pKa then deprotonation occurs When pH< pKa then protonation occur
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A: In the given reaction, the stereochemistry of the product remains unchanged as the reaction is…
Q: s. An appropriate dipole distribution? B. S0 D.30 26. Thioglycolic acid, HSCH,CO.H, a substance used…
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Q: could you rxplain the answer to #2? A) XX YY B) SS -- XX c) YY TT D) zz Ss 22 XX 2. Which of the…
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Q: The peptide segment shown below is part of a right-handed alpha helix. Please indicate the hydrogen-…
A: There are 4 types of structure of protein- 1- primary 2- secondary 3- tertiary 4- quaternary For…
Q: 9. Give the general name of each of the following sugars based on the number of carbons and type of…
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Q: H2N- CH-C- NH- CH2-C-NH-CH2- NH-CH-C-NH-CH-C-OH CH2 CH2 CH2 CH Compound A (Leu-enkephalin) H3C CH3…
A: Since you have asked multiple questions we will answer the first one for you. To get the remaining…
Q: Which of the following amino acids is polar acidic? OH CH3 CH, H,N*-C-c-o H,C-CH, H,C CH-C-o H-C-OH…
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Q: Another method to form a peptide bond involves a two-step process Reaction of the p-nitrophenyl…
A: Steps of synthesis is shown below:
Q: Illustrated here are the four stereoisomers of an amino acid that has two steeocenters. Which…
A: Since you have posted a question with multiple questions, we will solve first question for you. To…
Q: What are the alpha-amino acids (AA1, AA2, AA3) needed to complete the following synthesis?…
A:
Q: Consider the dipeptide (Pep) of a histidine and a lysine residue, with the neutral form pictured.…
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Q: Preparation of aspirin was done as follows, the reagent X is: COOH + CH;-C-0-C-CH, Y +CH3COOH HO…
A: Aspirin is the common name for the compound acetylsalicylic acid, widely used as a fever reducer and…
Q: (SYN) Show how to synthesize (a) Ser-Phe and (b) Leu-Ala-Met, using the scheme similar to the one in…
A: (a) Ser-Phe:
Q: BrCN
A: The given peptide is, The given reagent is BrCN.
Q: Glycine has pKa values of 2.34 and 9.60. At what pH does glycine exist in the indicated form?
A: In the given form of glycine,
Q: 20. After treatment with peroxyformic acid, the peptide hormone vasopressin is partially hydrolyzed.…
A: In the peptide chain , amino group is at the left . By looking at the fragments pattern we get the…
Q: Suppose you mix cysteine, leucine, proline and isoleucine together and allow them to form…
A: As per our company guidelines we are supposed to answer only one question. Kindly repost other…
Q: 7. Determine the net charge at pH 6 on each peptide shown below. The pKa's of relevant side chain…
A: We have to determine the net charge on the peptide
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Q: please explain why this happends, im having trouble in this section. Part A Chymotrypsin, an enzyme…
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Q: (B.) 45 Whhat is the expected structure of alanine, 11N G COOH CH in a neutral nedium HN--COOH H,N…
A: in Q.No 45 the expected structure of alanine in neutral solution. we know that the neutral…
Q: (a) The isoelectric point (pI) of phenylalanine is pH 5.5. Draw the structure of the major form of…
A: Answer (a):
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- A novel new method of peptide synthesis involves formation of an amide bond by reaction of an a-keto acid with an N-alkylhydroxylamine. OH R CO2 R' R R' + CO2 + H2O Draw curved arrows to show the movement of electrons in the following step of the reaction mechanism. Arrow-pushing Instructions X R :0: :O: R' H:OH H-A بد R :O: Nx- R' H2O CO2 A H- (18In the reaction shown below, what happens to ENERGY? 3 4 H H N-C-C | H H H I O | H OH ↓ H H H R | || I 1 N-C-C-N-C-C Peptide Bond H N-C-C I H I H =0 =0 OH energy comes "out" of or "exits" the reaction OH energy goes both "in/enters" and "out/exits" the reaction energy is not involved in this reaction in any way energy goes "into" or "enters" the reaction: 0: OH + :OH₂ b Draw curved arrows to show the rearrangement of electrons in the first step of aspirin hydrolysis. Arrow-pushing Instructions XT :O: OH HIO: :0 H :0: :0
- 1. y which mainly › time, net- ral rent ters. Phenobarbital 1090 10 Following is a structural formula for aspartame, an ar- tificial sweetener about 180 times as sweet as sucrose (table sugar). O NH3 H egy N Aspartame HOO HO HO HOOH + HO O OCH3 (f) Draw structural formulas for the products of com- plete hydrolysis of aspartame in aqueous NaOH. Show each product as it would be ionized in this solution.CH Post Lab ET O 44 Is saloviglvoyig'lo wouna inenimob stotis W A+H3N-CH-C-OH F CH-CH3 CH3 5. The structure of amino acid valine (Val) is as follows: The pKa for the carboxylic acid group is 2.29; the pKa for the protonated amine group is 9.74. What is the pl value of Val?Covalent enzyme catalysis involves the formation of a transient covalent bond between an enzyme and its substrate Below is the general structure of a commonly encountered so-called acyl-enzyme intermediate Ent- NH OH+Ent Select amino acid residues from the table beliow that have side chains with the enzyme reactive groups indicated in the above reaction (if more than one, start with lowest numbered first. Amino acid No 3-detter code What is the chemical name of the acyl-enzyme intermediate compound (acylimidazole, anhydride, ester, Schif base, thioester? 2) 3 HN HO HO HO HO (5) 6 HN HD HO HN HO HO 03 15 HN HN HO HO HO HO 08 09 20 HO
- The shaded area in the following diagram shows CH₂ CH | H CO-H-N N-H-O -CH₂ C-OH-N Gly 193 H RN Covalent bond formation between a catalytic amino acid residue and the substrate during chymotrypsin catalysis. Acid-base catalysis by a catalytic residue in chymotrypsin. Oxyanion hole which stabilizes substrate binding in chymotrypsin catalysis. Oxyanion hole which stabilizes transition state in chymotrypsin catalysis. Low barrier hydrogen bond formation between the transition state and one of the catalytic residues of chymotrypsin. ?The final major product of the following Edman reaction is CH3 NH₂ 13 Ph. Ph. Ph S ZH HO Ph—N=C Peptide HN -CH₂ SH O + Ph-N=C=S CH₁ peptide -CH₂ CH, النتتنامى -NH mais aus peptidewrite the mayor produob formed by the to llow ng veaction, Assume that you have enough of each reagont/ Reactant to drive bhe veactrion to Completiion. Assume bhet thore i's protic wk up alone as neee ssary mg By NaoH 아 Y>ト
- Hydrophobic tails Hydrophilic head Question 2 O P-O 1 12 CH-CH-CH o CHOCIO -3 -4 2 3 Hydrophilic head Hydrophobic tails (a) Structural formula (b) Space-filling model Which part of the molecule is the glycerol moiety? (c) Phospholipid symbol 4 2 3Tyrosine is catabolized by a series of steps that include a double-bond isomerization and a retro-Claisen condensation. Draw curved arrows to show the movement of electrons in this step of the reaction mechanism. Arrow-pushing Instructions X :0: CO2 H :0: :0: H ستيد - منتد OH2 .CO₂ -O₂C :ÖH2 یا SWhat are the most likely products formed from mixing the following neutral compounds? HINT: The most acidic proton in the acid will be transferred to the most basic site in the base. OH НО A В C D НО О А ABC В о с НО + OH OH NH₂ NH₂ + NH3 NH3 NH₂2