a multi-step synthesis for the indicated 1,3,5-trisubstituted benzene only using reactions discussed in class and in the text book. Be sure to indicate ALL necessary reagents and isolated intermediate products. Me HN steps and Me. Me only sources of carbon in final product Me

a multi-step synthesis for the indicated 1,3,5-trisubstituted benzene only using reactions discussed in class and in the text book. Be sure to indicate ALL necessary reagents and isolated intermediate products. Me HN steps and Me. Me only sources of carbon in final product Me

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter16: Aldehydes And Ketones

Section: Chapter Questions

Problem 16.63P

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Concept explainers

Reactions of Ethers

Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.

Epoxides

Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.

Williamson Ether Synthesis

An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.

Question

4) Starting from benzene and propionic anhydride as the only sources of carbon in the final product, propose
a multi-step synthesis for the indicated 1,3,5-trisubstituted benzene only using reactions discussed in
class and in the text book. Be sure to indicate ALL necessary reagents and isolated intermediate products.
Me
HN
steps
and
Ме
Me
only sources of carbon in
final product
Me

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