A girl complaints of acute abdominal pain on and off with tingling sensation of limbs. She had a history of eating paint from the wall of newly built house. Which of the following enzyme deficiency will be the cause of her condition? a. ALA dehydratase b. ALA synthase c. Coproporphyrinogen synthase d. Heme synthase
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- Sideroblastic anemia is observed in the deficiency of which of the following? * (Please choose one correct answer only) A. Thiamin B. Pyridoxine C. Cyanocobalamin D. NiacinAlpha-glucosidase inhibitors are contraindicated in all of the following cases, except:A. Diabetic ketoacidosisA. Liver cirrhosisB. HypertensionC. Large abdominal herniasD. Ulcerative colitisA patient presenting in musty odour and hypopigmentation has also presented with high levels of phenyl pyruvate in their blood. Which enzyme is upregulated? A. Phenylalanine dehydrogenase B. Phenylalanine hydroxylase C. Transaminase D. Arginase
- Indicate what will happen ( increase, decrease or no effect) tothe activity of the enzyme or rate of the metabolic pathway in the given conditions a. release of glucagon in the blood to the activity of carnitine acyl transferase 1 b. high malonyl CoA to the activity of carnitine acyl transferase I C. Epinephrine to the activity og glycogen synthase d. high citrate to the activity of acetyl CoA carboxylase e. high acetyl CoA to ketogenesisWhat is the most dangerous adverse effect following use of biguanides?A. Lactic acidosisB. HypoglycaemiaC. Diabetic ketoacidosisD. HyperosmolalityE. HyperglycaemiaOne day after sinulog, a 37 year old alcoholic male was brought to medical emergency department of SWU medical center in semi-conscious state. He was out of muscle coordination, with vision changes and somehow confabulating (making up stories). Which of the following vitamins can be used as a part of the treatment? * (Please choose one correct answer only) A. Cyanocobalamin B. Thiamin C. Folic acid D. Pantothenic acid
- Fill in the blanks and explain the relationship between the paired words/phrases a. methotrexate: dihydrofolate reductase; ___________: thymidylate synthase b. __________: aspartate; purine: glycineDefine the following terms: a. one-carbon metabolism b. para-aminobenzoic acid c. cobalamin d. pernicious anemia e. intrinsic factorWhich of the following caused your patient’s hyperglycemia?a. treatment for anaphylactic shock (systemic anaphylaxis)b. the presence of Glut-2 on beta cells in the pancreasc. the secretion of amylind. the presence of Glut-4 on adipose tissuee. hyponatremia
- A six year old boy dies of heart failure. He had mental retardation, short stature, course facial features, corneal, clouding, a large tongue, short, broad fingers, and skeletal dysplasia. He was normal at birth, progressive mental, and physical deterioration began at age 6 month. Examination at autopsy shows cornary artery thickening, and a tracheal narrowing. The most likely cause of these abnormalities is a deficiency of which of the following enzymes? A) alpha 1 antitrypsin B) galactocerebrosidase C) glycogen phosphorylase D) alpha -L- iduronidase E) type IV CollagenaseDefine the following terms:a. cytochrome P450b. mixed-function oxidasec. flavin-containing monooxygenased. detoxicatione. detoxificationAll of the following are true with respect to alpha-glucosidase inhibitor, except:A. It inhibits intestinal alpha-glucosidase B. It decreases enzymatic conversion of oligo- to monosaccharidesC. It lowers postprandial glucoseD. It causes gastrointestinal disturbances.E. It may cause development of hypertension.