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Chemistry
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- Answer the following questions:1. If excipients do not have pharmacodynamic activity, how do excipients affect the performance of the drug product?2. What is meant by the rate-limiting step in drug bioavailability from a solid oral drug product?3. What is the usual rate-limiting step for a poorly soluble and highly permeable drug (BCS 2)?4. How could the manufacturing process affect drug product performance?5. Drug absorption involves at least three distinct steps: dissolution, permeation, and disposition during transit in GI (an additional step of drug disposition in the body is involved as well for bioavailability). How are these processes validated in vitro when the in vivo requirement for drug bioavailability is waived?6. What is meant by “sink” conditions?7. What physical or chemical properties of a drug substance are important in designing a drug for (a) oral administration or (b) parenteral administration?8. For a lipid-soluble drug that has very poor aqueous solubility, what…1. How many ml of propofol (10 mg/ml) is necessary to induce a patient weighing 30 kg for surgery at a dose of 6 mg/kg? 2.How many mL of Midazolam (5mg/ml) should be given to a patient weighing 3.6 kg at a dose of 0.3mg/kg? 3.A drug follows linear one compartment pharmacokinetics, ke = 0.14 hr¹ and volume of distribution 18 L. • Calculate a suitable i.v. bolus dose to maintain plasma drug concentrations above 6 mg/L for 8 hours. What is the initial plasma concentration? (C) • What is half life of this drug? (t1/2) Please select one: a.C-16.5 mg/L t1/2=5 h b.C=14 mg/L 11/2=2.5 h c.C=17.5 mg/L 11/2=3 h d.C=20.6 mg/L t1/2=5 h e.C-18.4 mg/L t1/2=5 h
- Please help me out ... The drug dosage for the patient is calculated using a BSA of 1.9m2. If the order is 15mg per m2, how many milligrams is the desired dose?SOLVE THE FOLLOWING PROBLEMS OF DOSE CALCULATION, SHOW THE CALCULATIONS FOR EACH OF THEY: 1. An arthritic patient is taking 2 1/2mg of Rymadil three times a day. If each tablet contains 5mg, how many tablets will the patient take in 7 days? 2. The doctor orders Librium 50mg IM, it is available in a 100mg/ml concentration How many ml should be injected? 3. A Doctor prescribes procaine penicillin G for a 25lb patient and his dose is 40,000 units/kg. The concentration of the drug is 300,000 U/mL. How many mL should be managed? 4. A patient cuts his leg with barbed wire and develops an infection. The doctor indicates 500mg of amoxicillin BID, for 10 days. The capsules are available in 250mg. How many capsules should be dispensed? 5. A patient has worms. The prescribed treatment is orally at a rate of 1cc/10lbs. If he @ patient weighs 7 lbs, how many cc should be given? IEstimate the new dose and dosing interval for morphine, a high extraction ratio drug in a patient with a Child-Pugh score of 8 if the drug is normally given at a dose of 30 mg every 8 hours. A) 7.5 mg every 8 hours B) 22.5 mg every 8 hours C) 30 mg every 6 hours D) 30 mg every 12 hours
- SOLVE THE FOLLOWING PROBLEMS OF DOSE CALCULATION, SHOW THE CALCULATIONS FOR EACH OF THEY: 10. To anesthetize a patient, a 10 ml bottle of Ketamine is available at a concentration at 10% If the Ketamine dose in patients is 15 mg/Kg and the patient weighs 4 lbs. Calculate: a) Weight of the patient in Kg. b) mg of Ketamine needed to anesthetize the patient. c) Volume in ml of Ketamine.Give one advantage and one disadvantage of pharmaceutical solid dosage forms. Explain each advantage and disadvantage thoroughly.1. Study the given drug label and answer the question that follows. Show your solution How many total milliliters of diluent are used? What is the final concentration for each drug? a. b. C. How many milliliters are administered to give amoxicillin 500 mg/clavulanate 125 mg? J 343598 00451 AUGMENTIN 250 mg/5 mL 250 mg/5 mL NDC 43598-004-51 Directions for mixing: Tap bottle until all powder flows freely. Add approximately 2/3 of total water for reconstitution (total=65) shake vigorously to wet powder. Add remaining water, again shake vigorously. Dosage: See accompanying prescribing information. Keep tightly closed. Shake well before using. Must be refrigerated. Diecard after 10 days. Your answer AUGMENTIN® AMOXICILLIN/CLAVULANATE POTASSIUM FOR ORAL SUSPENSION When reconstituted, each 5 mL contains: AMOXICILLIN, 250 MG, as the trihydrate CLAVULANIC ACID, 62.5 MG, as clavulanate potassium 75 mL (when reconstituted) DR.REDDY'S Rx only Use only if inner seal is intact. Not contents:…
- Solve the solution medication problem. Round to nearest tenth. Order: ABC Medication 300mg Stock: ABC Medication 15% solution. How many mL will give you?SOLVE THE FOLLOWING PROBLEMS OF DOSE CALCULATION, SHOW THE CALCULATIONS FOR EACH OF THEY: 1. Atropine is given in doses of .5mg/kg. How much will a patient who weighs 3.5 lbs receive? An arthritic patient is taking 2 1/2mg of Rymadil three times a day. If each tablet contains 5mg, how many tablets will the patient take in 7 days? 2.Furosemide is packaged as 10 mg/mL. A pharmacy technician must make a preparation totaling 25 mL of 2 mg/mL concentration. How much drug and how much diluent are used? (Textbook says use %w/v to calculate and the answer key says 5 mL concentrate; 20 mL diluent. I'm looking for how to set up and solve this problem.)