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3. A 2-year-old child was taken to the hospital. His mother said that he vomited frequently, especially after feedings. The child's weight and physical development were below normal. His hair, although dark, contained patches of white. A urine sample treated with ferric chloride (FeCl,) gave a green color characteristic of the presence of phenylpyruvate. Quantitative analysis of urine samples revealed the presence of phenylalanine 7.0 uMol/L (0.01 in health), phenylpyruvate 7. Decarboxylation of Some Amino Acids, Synthesis of Neurotransmitters and Hormones 457 4.8 uMol/L (0 in health) and phenyllactate (0 in health). Suggest, which enzyme might be deficient in this child? Why does the abnormal pathway come into play under these conditions? c) write down the scheme of an alternative metabolic pathway of the substrate;

3. A 2-year-old child was taken to the hospital. His mother said that he vomited frequently, especially after feedings. The child's weight and physical development were below normal. His hair, although dark, contained patches of white. A urine sample treated with ferric chloride (FeCl,) gave a green color characteristic of the presence of phenylpyruvate. Quantitative analysis of urine samples revealed the presence of phenylalanine 7.0 uMol/L (0.01 in health), phenylpyruvate 7. Decarboxylation of Some Amino Acids, Synthesis of Neurotransmitters and Hormones 457 4.8 uMol/L (0 in health) and phenyllactate (0 in health). Suggest, which enzyme might be deficient in this child? Why does the abnormal pathway come into play under these conditions? c) write down the scheme of an alternative metabolic pathway of the substrate;

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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3. A 2-year-old child was taken to the hospital. His mother said that he vomited frequently, especially after feedings. The child's weight and physical development were below normal. His hair, although dark, containcd patches of white. A urine sample treated with ferric chloride (FeCl,) gave a green color characteristic of the presence of phenylpyruvate. Quantitative analysis of urine samples revealed the presence of phenylalanine 7.0 uMol/L (0.01 in health), phenylpyruvate 8.7. Decarboxylation of Some Amino Acids, Synthesis of Neurotransmitters and Hormones 457 4.8 uMol/L (0 in health) and phenyllactate (0 in health). Suggest, which enzyme might be deficient in this child? Why does the abnormal pathway come into play under these conditions? c) write down the scheme of an alternative metabolic pathway of the substrate;
Transcribed Image Text:3. A 2-year-old child was taken to the hospital. His mother said that he vomited frequently, especially after feedings. The child's weight and physical development were below normal. His hair, although dark, containcd patches of white. A urine sample treated with ferric chloride (FeCl,) gave a green color characteristic of the presence of phenylpyruvate. Quantitative analysis of urine samples revealed the presence of phenylalanine 7.0 uMol/L (0.01 in health), phenylpyruvate 8.7. Decarboxylation of Some Amino Acids, Synthesis of Neurotransmitters and Hormones 457 4.8 uMol/L (0 in health) and phenyllactate (0 in health). Suggest, which enzyme might be deficient in this child? Why does the abnormal pathway come into play under these conditions? c) write down the scheme of an alternative metabolic pathway of the substrate;
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