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13. If electrons are not flowing through the electron transport chain, how will the proton in the intermembrane space and the matrix be affected? concentration

13. If electrons are not flowing through the electron transport chain, how will the proton in the intermembrane space and the matrix be affected? concentration

Human Physiology: From Cells to Systems (MindTap Course List)
Human Physiology: From Cells to Systems (MindTap Course List)
9th Edition
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Lauralee Sherwood
Chapter2: Cell Physiology
Section: Chapter Questions
Problem 2TAHL
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Part 3: Disrupting the ETC Several conditions or chemicals can eliminate the H* gradient in the mitochondria. One condition is cyanide poisoning. Cyanide binds to Complex IV in the electron transport chain (see figure 3 below) and prevents the binding of oxygen. This blocks the flow of electrons through the ETC. Cyanide acts like a road block on a highway. Electron transport chain ATP synthase Intermembrane space Inner mitochondrial- membrane NADH NAD + (H+ (H+) Mitochondrial matrix H+ (H+ FADH₂ FAD (H+) (H+) H+ (H+ (H+ (H+ Cyt c (H+ O H (H+ (H+ 2 electrons 1/2 of 2 free hydrogen exiting ETC an O₂ ions H+ (H+ (H+ (H+ - H₂0 x2 H* (H+) ADP + PO, (H+ H+ (H+ molecule Figure 3: Oxidative Phosphorylation and Chemiosmosis ATPO https://upload.wikimedia.org/wikipedia/commons/2/27/2508 The Electron Transport Chain.jpg OpenStax College, CC BY 3.0 <https://creativecommons.org/licenses/by/3.0>, via Wikimedia Commons 13. If electrons are not flowing through the electron transport chain, how will the proton concentration in the intermembrane space and the matrix be affected? 14. Will a mitochondrion affected by cyanide, be in an active or inactive state? Based on your calculations of pH in Part 2, what do you expect the pH in the matrix and the intermembrane space of a mitochondrion affected by cyanide to be? Sketch your answer in the graph below by adding appropriate bars over "Cyanide". 5
Transcribed Image Text:Part 3: Disrupting the ETC Several conditions or chemicals can eliminate the H* gradient in the mitochondria. One condition is cyanide poisoning. Cyanide binds to Complex IV in the electron transport chain (see figure 3 below) and prevents the binding of oxygen. This blocks the flow of electrons through the ETC. Cyanide acts like a road block on a highway. Electron transport chain ATP synthase Intermembrane space Inner mitochondrial- membrane NADH NAD + (H+ (H+) Mitochondrial matrix H+ (H+ FADH₂ FAD (H+) (H+) H+ (H+ (H+ (H+ Cyt c (H+ O H (H+ (H+ 2 electrons 1/2 of 2 free hydrogen exiting ETC an O₂ ions H+ (H+ (H+ (H+ - H₂0 x2 H* (H+) ADP + PO, (H+ H+ (H+ molecule Figure 3: Oxidative Phosphorylation and Chemiosmosis ATPO https://upload.wikimedia.org/wikipedia/commons/2/27/2508 The Electron Transport Chain.jpg OpenStax College, CC BY 3.0 <https://creativecommons.org/licenses/by/3.0>, via Wikimedia Commons 13. If electrons are not flowing through the electron transport chain, how will the proton concentration in the intermembrane space and the matrix be affected? 14. Will a mitochondrion affected by cyanide, be in an active or inactive state? Based on your calculations of pH in Part 2, what do you expect the pH in the matrix and the intermembrane space of a mitochondrion affected by cyanide to be? Sketch your answer in the graph below by adding appropriate bars over "Cyanide". 5
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